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High affinity nerve growth factor receptor

Summary

UniProt ID

P35739

Gene Symbol

Ntrk1
Trk
Trka

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P35739

Annotation

Keyword

ATP-binding
Alternative splicing
Cell membrane
Developmental protein
Differentiation
Disulfide bond
Endosome
Glycoprotein
Immunoglobulin domain
Leucine-rich repeat
Neurogenesis
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Gene Ontology (GO)

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GO Term
positive regulation of protein phosphorylation
protein phosphorylation
nervous system development
learning or memory
negative regulation of cell population proliferation
B cell differentiation
programmed cell death involved in cell development
positive regulation of neuron projection development
olfactory nerve development
response to nutrient levels

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GO Term
Golgi membrane
cytoplasm
plasma membrane
axon
protein-containing complex
dendrite
neuronal cell body
receptor complex
recycling endosome membrane
early endosome membrane

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GO Term
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
kinase binding
identical protein binding
protein homodimerization activity
transmembrane receptor protein serine/threonine kinase activity
GPI-linked ephrin receptor activity
neurotrophin receptor activity
neurotrophin p75 receptor binding
ATP binding

Annotation information from UniProt.

Sequence

MLRGQRHGQLGWHRPAAGLGGLVTSLMLACACAASCRETCCPVGPSGLRCTRAGTLNTLRGLRGAGNLTELYVENQRDLQRLEFEDLQGLGELRSLTIVKSGLRFVAPDAFHFTPRLSHLNLSSNALESLSWKTVQGLSLQDLTLSGNPLHCSCALLWLQRWEQEDLCGVYTQKLQGSGSGDQFLPLGHNNSCGVPSVKIQMPNDSVEVGDDVFLQCQVEGQALQQADWILTELEGTATMKKSGDLPSLGLTLVNVTSDLNKKNVTCWAENDVGRAEVSVQVSVSFPASVHLGKAVEQHHWCIPFSVDGQPAPSLRWFFNGSVLNETSFIFTQFLESALTNETMRHGCLRLNQPTHVNNGNYTLLAANPYGQAAASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSRDPVEKKDETPFGVSVAVGLAVSAALFLSALLLVLNKCGQRSKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIMENPQYFSDTCVHHIKRQDIILKWELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVRFFGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFSTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQGRELERPRACPPDVYAIMRGCWQREPQQRLSMKDVHARLQALAQAPPSYLDVLG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	Source
67	N-linked (GlcNAc...) asparagine	UniProt
121	N-linked (GlcNAc...) asparagine	UniProt
190	N-linked (GlcNAc...) asparagine	UniProt
204	N-linked (GlcNAc...) asparagine	UniProt
255	N-linked (GlcNAc...) asparagine	UniProt
264	N-linked (GlcNAc...) asparagine	UniProt
320	N-linked (GlcNAc...) asparagine	UniProt
325	N-linked (GlcNAc...) asparagine	UniProt
341	N-linked (GlcNAc...) asparagine	UniProt
361	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
ARMS-mediated activation	Rattus norvegicus
Frs2-mediated activation	Rattus norvegicus
PI3K/AKT activation	Rattus norvegicus
Retrograde neurotrophin signalling	Rattus norvegicus
TRKA activation by NGF	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements