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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Hydroxymethylglutaryl-CoA lyase, mitochondrial
Summary
- UniProt ID
- P35914
- Gene Symbol
-
- HMGCL
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P35914
- PubChem
- P35914
- SwissLipids
- The Human Metabolome Database
- HMDBP00009
- The O-GlcNAc Database
- P35914
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Disease variant
- Disulfide bond
- Lipid metabolism
- Lyase
- Metal-binding
- Mitochondrion
- Peroxisome
- Reference proteome
- Transit peptide
- Gene Ontology (GO)
| GO Term |
|---|
| lipid metabolic process |
| ketone body biosynthetic process |
| mitochondrion organization |
| leucine catabolic process |
| GO Term |
|---|
| protein-containing complex |
| mitochondrion |
| mitochondrial matrix |
| peroxisome |
| cytosol |
| peroxisomal matrix |
| GO Term |
|---|
| metal ion binding |
| manganese ion binding |
| magnesium ion binding |
| hydroxymethylglutaryl-CoA lyase activity |
| structural molecule activity |
Sequence
MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Peroxisomal protein import | Homo sapiens |
| Synthesis of Ketone Bodies | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110431 | dilated cardiomyopathy 1I | |
| DOID:0110432 | dilated cardiomyopathy 1NN | |
| DOID:0110433 | dilated cardiomyopathy 1E | |
| DOID:0110434 | dilated cardiomyopathy 1Z | |
| DOID:0110435 | dilated cardiomyopathy 1GG | |
| DOID:0110436 | dilated cardiomyopathy 1L | |
| DOID:0110437 | dilated cardiomyopathy 1K | |
| DOID:0110438 | dilated cardiomyopathy 1JJ | |
| DOID:0110439 | dilated cardiomyopathy 1P | |
| DOID:0110441 | dilated cardiomyopathy 2B |
