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Adenylate cyclase type 8

Summary

UniProt ID

P40146

Gene Symbol

Adcy8

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P40146
The Human Metabolome Database: HMDBP14646

Annotation

Keyword

ATP-binding
Alternative splicing
Cell membrane
Cell projection
Coated pit
Cytoplasmic vesicle
Glycoprotein
Lyase
Magnesium
Manganese
Metal-binding
Methylation
Phosphoprotein
Reference proteome
Repeat
Synapse
Transmembrane helix
cAMP biosynthesis

Gene Ontology (GO)

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GO Term
adenylate cyclase-activating G protein-coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
cAMP-mediated signaling
positive regulation of insulin secretion involved in cellular response to glucose stimulus
protein complex oligomerization
protein homooligomerization
regulation of cytosolic calcium ion concentration
cellular response to calcium ion
cellular response to glucose stimulus
cAMP biosynthetic process

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GO Term
postsynaptic density
clathrin-coated vesicle membrane
presynaptic membrane
plasma membrane raft
presynaptic active zone
excitatory synapse
Schaffer collateral - CA1 synapse
hippocampal mossy fiber to CA3 synapse
glutamatergic synapse
neuronal cell body membrane

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GO Term
protein homodimerization activity
protein heterodimerization activity
protein dimerization activity
phosphatase binding
protein phosphatase 2A binding
metal ion binding
calcium- and calmodulin-responsive adenylate cyclase activity
actin binding
adenylate cyclase activity
calmodulin binding

Annotation information from UniProt.

Sequence

MELSDVHCLSGSEELYTIHPTPPAADGGSGSRPQRLLWQTAVRHITEQRFIHGHRGGGGGGSRKASNPAGSGPNHHAPQLSSDSVLPLYSLGSGERAHNTGGTKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVTLQVLIPRLAVFSINQVLAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRFVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLSGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLSLPEDIVKESVSCSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRLMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLARNVIIFASILINFLGAVINILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLSYDNLNHSGEDFLGTKEASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKDLREHNENMLRNILPGHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENSNSGIIKSHYNRRTLLTPSGPEPGAQAEGTDKSDLP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
814	N-linked (GlcNAc...) asparagine	UniProt
818	N-linked (GlcNAc...) asparagine	UniProt
885	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Adenylate cyclase activating pathway	Rattus norvegicus
Adenylate cyclase inhibitory pathway	Rattus norvegicus
G alpha (z) signalling events	Rattus norvegicus
Hedgehog 'off' state	Rattus norvegicus
PKA activation	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements