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Thrombopoietin

Summary
UniProt ID
P40225
Gene Symbol
  • MGDF
  • THPO
Gene ID
7066
Organism
Homo sapiens (human)
GlyConnect
GlyGen
P40225
PubChem
P40225
Re-Glyco
P40225
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Cytokine
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Hormone
  • Reference proteome
  • Secreted
  • Signal
Gene Ontology (GO)
Displaying all 2 entries
GO Term
extracellular region
extracellular space
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTTAVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSLDQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 17 in total
Position Description PubMed ID GlyTouCan ID Source
22 O-linked (GalNAc...) serine
58 O-linked (GalNAc...) threonine
131 O-linked (GalNAc...) threonine
179 O-linked (GalNAc...) threonine
180 O-linked (GalNAc...) threonine
184 O-linked (GalNAc...) serine
197 N-linked (GlcNAc...) (complex) asparagine
206 N-linked (GlcNAc...) (complex) asparagine
213 O-linked (GalNAc...) threonine
234 N-linked (GlcNAc...) (complex) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying 1 entry
Pathway Name Organism
Platelet Aggregation (Plug Formation) Homo sapiens
Disease
Displaying all 5 entries
DO ID Disease Name Source
DOID:0061002 congenital amegakaryocytic thrombocytopenia 2
DOID:12449 aplastic anemia
DOID:1588 thrombocytopenia
DOID:2224 essential thrombocythemia
DOID:2228 thrombocytosis
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025