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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Malate dehydrogenase, mitochondrial
Summary
- UniProt ID
- P40926
- Gene Symbol
-
- MDH2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Disease variant
- Epilepsy
- Glycoprotein
- Mitochondrion
- NAD
- Oxidoreductase
- Phosphoprotein
- Reference proteome
- Transit peptide
- Tricarboxylic acid cycle
- Gene Ontology (GO)
| GO Term |
|---|
| tricarboxylic acid cycle |
| aerobic respiration |
| oxaloacetate metabolic process |
| malate metabolic process |
| NADH metabolic process |
| gluconeogenesis |
| GO Term |
|---|
| nucleus |
| cytoplasm |
| membrane |
| extracellular exosome |
| mitochondrion |
| mitochondrial matrix |
| cytosol |
| GO Term |
|---|
| RNA binding |
| protein self-association |
| L-malate dehydrogenase activity |
| malate dehydrogenase (NADP+) activity |
Sequence
MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK
Glycosylation Sites
G49108TO
G70994MS
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Citric acid cycle (TCA cycle) | Homo sapiens |
| Malate-aspartate shuttle | Homo sapiens |
| Mitochondrial protein degradation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050771 | pheochromocytoma | |
| DOID:0050773 | paraganglioma | |
| DOID:0050811 | congenital adrenal hyperplasia | |
| DOID:0080348 | Alzheimer's disease 1 | |
| DOID:0080433 | developmental and epileptic encephalopathy 51 | |
| DOID:0110035 | Alzheimer's disease 2 | |
| DOID:0110037 | Alzheimer's disease 5 | |
| DOID:0110038 | Alzheimer's disease 6 | |
| DOID:0110039 | Alzheimer's disease 7 | |
| DOID:0110041 | Alzheimer's disease 8 |
