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Metabotropic glutamate receptor 5

Summary

UniProt ID

P41594

Gene Symbol

GRM5
GPRC1E
MGLUR5

Organism

Homo sapiens (human)

External Links

GlyGen: P41594
PubChem: P41594
The Human Metabolome Database: HMDBP02180
The O-GlcNAc Database: P41594
O-GlcNAcAtlas: P41594

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Methylation
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 17 in total

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GO Term
positive regulation of long-term neuronal synaptic plasticity
regulation of DNA-templated transcription
desensitization of G protein-coupled receptor signaling pathway
phospholipase C-activating G protein-coupled glutamate receptor signaling pathway
protein kinase C-activating G protein-coupled receptor signaling pathway
learning
positive regulation of MAPK cascade
calcium-mediated signaling using intracellular calcium source
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
cellular response to amyloid-beta

Displaying **all 9** entries
GO Term
cytoplasm
plasma membrane
dendrite
astrocyte projection
glutamatergic synapse
dendritic shaft
dendritic spine
Schaffer collateral - CA1 synapse
postsynaptic density membrane

Displaying **all 9** entries
GO Term
A2A adenosine receptor binding
protein tyrosine kinase binding
identical protein binding
adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
G protein-coupled receptor activity
glutamate receptor activity
protein tyrosine kinase activator activity
G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential

Annotation information from UniProt.

Sequence

MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGNGGRATMSSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGGPESPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTLIIRDYTQSSSSL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 9** entries
Position	Description	GlyTouCan ID	Source
88	N-linked (GlcNAc...) asparagine		UniProt GlyGen
210	N-linked (GlcNAc...) asparagine		UniProt GlyGen
378	N-linked (GlcNAc...) asparagine		UniProt GlyGen
382	N-linked (GlcNAc...) asparagine		UniProt GlyGen
445	N-linked (GlcNAc...) asparagine		UniProt GlyGen
734	N-linked (GlcNAc...) asparagine		UniProt GlyGen
854		G49108TO	GlyGen
1050		G49108TO	GlyGen The O-GlcNAc Database
1051		G49108TO	GlyGen The O-GlcNAc Database