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Thrombopoietin

Summary

UniProt ID

P42705

Gene Symbol

THPO
TPO

Organism

Canis lupus familiaris (dog)

External Links

PubChem: P42705

Annotation

Keyword

Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Hormone
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying **all 7** entries
GO Term
thrombopoietin-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
cell population proliferation
positive regulation of megakaryocyte differentiation
positive regulation of hematopoietic stem cell proliferation
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
positive regulation of protein phosphorylation

Displaying **all 2** entries
GO Term
extracellular region
extracellular space

Displaying **all 3** entries
GO Term
cytokine activity
hormone activity
signaling receptor binding

Annotation information from UniProt.

Sequence

MELTELLLVVMLLLTARLDPCLPAPPACDPRLLNKMLRDSHVLHSRLSQCPDIYPLSTPVLLPAVDFSLGEWKTQKEQTKAQDVWGAVALLLDGVLAARGQLGPSCLSSLLGQLSGQVRLLLGALQGLLGTQLPPQGRTTTHKDPNAIFLSFQQLLRGKVRFLLLVAGPTLCAKQSQPTTAVPTNTSLFLTLRKLPNRTSGLLETNSSISARTTGSGLLKRLQGFRAKIPGLLNQTSRSLNQTPGHLSRTHGPLNGTHGLLPGLSLTALGAPDIPPGTSDMDALPPNLWPRYSPSPIHPPPGQYTLFSPLPTSPTPQNPLQPPPPDPSATANSTSPLLIAAHPHFQNLSQEE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	Source
185	N-linked (GlcNAc...) asparagine	UniProt
197	N-linked (GlcNAc...) asparagine	UniProt
206	N-linked (GlcNAc...) asparagine	UniProt
234	N-linked (GlcNAc...) asparagine	UniProt
255	N-linked (GlcNAc...) asparagine	UniProt
332	N-linked (GlcNAc...) asparagine	UniProt
347	N-linked (GlcNAc...) asparagine	UniProt