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MIRAGE
Pro-neuregulin-1, membrane-bound isoform
Summary
- UniProt ID
- P43322
- Gene Symbol
-
- Ndf
- Nrg1
- Organism
- Rattus norvegicus (Norway rat)
External Links
- Re-Glyco
- P43322
Annotation
- Keyword
-
- Alternative splicing
- Cell membrane
- Direct protein sequencing
- Disulfide bond
- EGF-like domain
- Glycoprotein
- Growth factor
- Immunoglobulin domain
- Reference proteome
- Secreted
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| neuron projection |
| neuronal cell body |
| synapse |
| postsynapse |
| presynaptic active zone membrane |
| GABA-ergic synapse |
| extracellular space |
| cytoplasm |
| plasma membrane |
| membrane |
Sequence
MSERKEGRGKGKGKKKDRGSRGKPGPAEGDPSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPENIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEFITGMPASTETAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLIKCAEKEKTFCVNGGECFTVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYMTSRRKRQETEKPLERKLDHSLVKESKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRQKLHDRLRQSLRSERSNLVNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREVETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESVISESNSVIMMSSVENSRHSSPAGGPRGRLHGLGGPRDNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSVAVSPFVEEERPLLLVTPPRLREKKYDHHPQQLNSFHHNPAHQSTSLPPSPLRIVEDEEYETTQEYESVQEPVKKVTNSRRAKRTKPNGHIANRLEMDSNTSSVSSNSESETEDERVGEDTPFLGIQNPLAASLEVAPAFRLAESRTNPAGRFSTQEELQARLSSVIANQDPIAV
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Downregulation of ERBB2 signaling | Rattus norvegicus |
| Downregulation of ERBB2:ERBB3 signaling | Rattus norvegicus |
| ERBB2 Activates PTK6 Signaling | Rattus norvegicus |
| ERBB2 Regulates Cell Motility | Rattus norvegicus |
| GRB2 events in ERBB2 signaling | Rattus norvegicus |
| GRB7 events in ERBB2 signaling | Rattus norvegicus |
| PI3K events in ERBB2 signaling | Rattus norvegicus |
| PI3K events in ERBB4 signaling | Rattus norvegicus |
| PI3K/AKT Signaling | Rattus norvegicus |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10652 | Alzheimer's disease | |
| DOID:11446 | sciatic neuropathy |
