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Interleukin-12 subunit beta

Summary

UniProt ID

P43432

Gene Symbol

Il12b

Organism

Mus musculus (house mouse)

External Links

GlyGen: P43432
PubChem: P43432
The O-GlcNAc Database: P43432

Annotation

Keyword

3D-structure
Cytokine
Disulfide bond
Glycoprotein
Immunoglobulin domain
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying entries **1 - 10** of 41 in total

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GO Term
positive regulation of T cell mediated cytotoxicity
natural killer cell activation involved in immune response
positive regulation of T-helper 1 type immune response
cell surface receptor signaling pathway
cell population proliferation
response to organic substance
immunoglobulin mediated immune response
cell migration
cytokine-mediated signaling pathway
natural killer cell activation

Displaying **all 10** entries
GO Term
endoplasmic reticulum lumen
Golgi lumen
external side of plasma membrane
cell surface
interleukin-23 complex
endosome lumen
interleukin-12 complex
extracellular region
extracellular space
cytoplasm

Displaying **all 8** entries
GO Term
protein-containing complex binding
identical protein binding
interleukin-23 receptor binding
protein heterodimerization activity
cytokine activity
growth factor activity
interleukin-12 alpha subunit binding
cytokine receptor activity

Annotation information from UniProt.

Sequence

MCPQKLTISWFAIVLLVSPLMAMWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	GlyTouCan ID	Source
47	N-linked (GlcNAc...) asparagine		UniProt GlyGen
122	N-linked (GlcNAc...) asparagine		UniProt GlyGen
132	N-linked (GlcNAc...) asparagine		UniProt GlyGen
220	N-linked (GlcNAc...) asparagine		UniProt GlyGen
		G49108TO	GlyGen The O-GlcNAc Database