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G protein-activated inward rectifier potassium channel 4

Summary

UniProt ID

P48544

Gene Symbol

GIRK4
KCNJ5

Gene ID

3762

Organism

Homo sapiens (human)

External Links

GlyGen: P48544
PubChem: P48544
The Human Metabolome Database: HMDBP08743
Re-Glyco: P48544

Annotation

Keyword

Disease variant
Long QT syndrome
Phosphoprotein
Potassium transport
Reference proteome
Transmembrane helix
Voltage-gated channel

Gene Ontology (GO)

Displaying **all 3** entries
GO Term
plasma membrane
voltage-gated potassium channel complex
I(KACh) inward rectifier potassium channel complex

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying **all 7** entries
GO Term
regulation of monoatomic ion transmembrane transport
membrane repolarization during atrial cardiac muscle cell action potential
ventricular cardiac muscle cell membrane repolarization
potassium ion transport
potassium ion transmembrane transport
regulation of heart rate by cardiac conduction
potassium ion import across plasma membrane

Displaying **all 3** entries
GO Term
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
G-protein activated inward rectifier potassium channel activity

Annotation information from UniProt.

Sequence

MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKCNVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDHVGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTPSCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
132				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Activation of G protein gated Potassium channels	Homo sapiens
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Homo sapiens

Disease

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060224	atrial fibrillation	Alliance of Genome Resources
DOID:0110654	long QT syndrome 13	Alliance of Genome Resources
DOID:446	primary hyperaldosteronism	Alliance of Genome Resources