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Mitogen-activated protein kinase 8

Summary

UniProt ID

P49185

Gene Symbol

Mapk8
Jnk1
Prkm8

Organism

Rattus norvegicus (Norway rat)

External Links

GlyGen: P49185
PubChem: P49185
The O-GlcNAc Database: P49185

Annotation

Keyword

ATP-binding
Biological rhythms
Cytoplasm
Nucleus
Phosphoprotein
Reference proteome
S-nitrosylation
Serine/threonine-protein kinase
Synapse

Gene Ontology (GO)

Displaying entries **1 - 10** of 59 in total

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GO Term
rhythmic process
response to steroid hormone
dendrite morphogenesis
modulation of chemical synaptic transmission
ossification
neuron migration
positive regulation of neuroblast proliferation
response to oxidative stress
response to UV
response to mechanical stimulus

Displaying entries **1 - 10** of 14 in total

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GO Term
perikaryon
mitochondrion
cytosol
podosome
nucleoplasm
basal dendrite
Schaffer collateral - CA1 synapse
nucleus
cytoplasm
axon

Displaying entries **1 - 10** of 13 in total

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GO Term
kinesin binding
JUN kinase activity
protein serine/threonine/tyrosine kinase activity
ATP binding
protein phosphatase binding
histone deacetylase regulator activity
protein kinase activity
protein serine/threonine kinase activity
kinase activity
enzyme binding

Annotation information from UniProt.

Sequence

MSRSKRDNNFYSVEIADSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCLKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPVSSPSVNDMSSMSTDPTLASD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
Activation of BIM and translocation to mitochondria	Rattus norvegicus
Activation of BMF and translocation to mitochondria	Rattus norvegicus
Activation of the AP-1 family of transcription factors	Rattus norvegicus
FCERI mediated MAPK activation	Rattus norvegicus
Interleukin-38 signaling	Rattus norvegicus
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	Rattus norvegicus
NRAGE signals death through JNK	Rattus norvegicus
Oxidative Stress Induced Senescence	Rattus norvegicus
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Rattus norvegicus