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Mitogen-activated protein kinase 8

Summary

UniProt ID

P49185

Gene Symbol

Mapk8
Jnk1
Prkm8

Organism

Rattus norvegicus (Norway rat)

External Links

GlyGen: P49185
PubChem: P49185
The O-GlcNAc Database: P49185

Annotation

Keyword

ATP-binding
Biological rhythms
Cytoplasm
Nucleus
Phosphoprotein
Reference proteome
S-nitrosylation
Serine/threonine-protein kinase
Synapse

Gene Ontology (GO)

Displaying entries **1 - 10** of 59 in total

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GO Term
rhythmic process
response to steroid hormone
dendrite morphogenesis
modulation of chemical synaptic transmission
positive regulation of protein metabolic process
cellular response to nitric oxide
type B pancreatic cell apoptotic process
positive regulation of neuron migration
positive regulation of apoptotic signaling pathway
SMAD protein signal transduction

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GO Term
basal dendrite
Schaffer collateral - CA1 synapse
perikaryon
mitochondrion
cytosol
podosome
nucleoplasm
nucleus
cytoplasm
axon

Displaying entries **1 - 10** of 13 in total

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GO Term
protein kinase activity
protein serine/threonine kinase activity
kinase activity
enzyme binding
histone deacetylase binding
protein serine kinase activity
protein serine/threonine kinase binding
kinesin binding
JUN kinase activity
protein serine/threonine/tyrosine kinase activity

Annotation information from UniProt.

Sequence

MSRSKRDNNFYSVEIADSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCLKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPVSSPSVNDMSSMSTDPTLASD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
Activation of BIM and translocation to mitochondria	Rattus norvegicus
Activation of BMF and translocation to mitochondria	Rattus norvegicus
Activation of the AP-1 family of transcription factors	Rattus norvegicus
FCERI mediated MAPK activation	Rattus norvegicus
Interleukin-38 signaling	Rattus norvegicus
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	Rattus norvegicus
NRAGE signals death through JNK	Rattus norvegicus
Oxidative Stress Induced Senescence	Rattus norvegicus
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Rattus norvegicus