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MIRAGE
Cyclin-dependent kinase 8
Summary
- UniProt ID
- P49336
- Gene Symbol
-
- CDK8
- Gene ID
- 1024
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Activator
- Alternative splicing
- Autism spectrum disorder
- Disease variant
- Intellectual disability
- Nucleus
- Reference proteome
- Repressor
- Serine/threonine-protein kinase
- Transcription regulation
- Gene Ontology (GO)
| GO Term |
|---|
| nucleus |
| nucleolus |
| protein-containing complex |
| nucleoplasm |
| cyclin-dependent protein kinase holoenzyme complex |
| mediator complex |
| CKM complex |
| GO Term |
|---|
| positive regulation of transcription by RNA polymerase II |
| G1/S transition of mitotic cell cycle |
Sequence
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 410 |
|
|||
| 411 |
|
|||
| 412 |
|
|||
| 413 |
|
|||
| 419 |
|
|||
| 420 |
|
|||
| 425 |
|
|||
| 437 |
|
|||
| 443 |
|
|||
| 444 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | Homo sapiens |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | Homo sapiens |
| Generic Transcription Pathway | Homo sapiens |
| MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis | Homo sapiens |
| NOTCH1 Intracellular Domain Regulates Transcription | Homo sapiens |
| PPARA activates gene expression | Homo sapiens |
| RSV-host interactions | Homo sapiens |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | Homo sapiens |
| Transcriptional regulation of white adipocyte differentiation | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:12930 | dilated cardiomyopathy |
