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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Summary
- UniProt ID
- P60484
- Gene Symbol
-
- PTEN
- MMAC1
- TEP1
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P60484
- PubChem
- P60484
- SwissLipids
- The Human Metabolome Database
- HMDBP01570
- The O-GlcNAc Database
- P60484
- O-GlcNAcAtlas
- P60484
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative initiation
- Alternative splicing
- Apoptosis
- Autism spectrum disorder
- Cell projection
- Cytoplasm
- Disease variant
- Isopeptide bond
- Lipid metabolism
- Lipid-binding
- Neurogenesis
- Nucleus
- Phosphoprotein
- Protein phosphatase
- Reference proteome
- Secreted
- Synapse
- Tumor suppressor
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| nucleus |
| cytoplasm |
| plasma membrane |
| neuron projection |
| cell projection |
| apical plasma membrane |
| PML body |
| Schmidt-Lanterman incisure |
| cytosol |
Sequence
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 227 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Downstream TCR signaling | Homo sapiens |
| Negative regulation of the PI3K/AKT network | Homo sapiens |
| Ovarian tumor domain proteases | Homo sapiens |
| PTEN Loss of Function in Cancer | Homo sapiens |
| Regulation of PTEN localization | Homo sapiens |
| Regulation of PTEN mRNA translation | Homo sapiens |
| Regulation of PTEN stability and activity | Homo sapiens |
| Synthesis of IP3 and IP4 in the cytosol | Homo sapiens |
| Synthesis of PIPs at the plasma membrane | Homo sapiens |
| TP53 Regulates Metabolic Genes | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:11603 | infant gynecomastia | |
| DOID:11612 | polycystic ovary syndrome | |
| DOID:11634 | myxedema | |
| DOID:1168 | familial hyperlipidemia | |
| DOID:117 | heart cancer | |
| DOID:11701 | selective IgA deficiency disease | |
| DOID:11713 | diabetic angiopathy | |
| DOID:11714 | gestational diabetes | |
| DOID:11725 | Cornelia de Lange syndrome | |
| DOID:11830 | myopia |
