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Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Summary

UniProt ID

P67775

Gene Symbol

PPP2CA

Organism

Homo sapiens (human)

External Links

GlyGen: P67775
PubChem: P67775
The Human Metabolome Database: HMDBP02514
The O-GlcNAc Database: P67775

Annotation

Keyword

3D-structure
Alternative splicing
Centromere
Chromosome
Cytoskeleton
Direct protein sequencing
Disease variant
Intellectual disability
Manganese
Meiosis
Metal-binding
Methylation
Nucleus
Phosphoprotein
Protein phosphatase
Reference proteome
Ubl conjugation

Gene Ontology (GO)

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GO Term
mitotic cell cycle
regulation of protein phosphorylation
mesoderm development
regulation of growth
T cell homeostasis
meiotic cell cycle
negative regulation of epithelial to mesenchymal transition
intracellular signal transduction
regulation of cell differentiation
positive regulation of protein serine/threonine kinase activity

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GO Term
nucleus
plasma membrane
microtubule cytoskeleton
membrane
synapse
extracellular exosome
mitochondrion
cytosol
membrane raft
protein phosphatase type 2A complex

Displaying **all 8** entries
GO Term
metal ion binding
myosin phosphatase activity
GABA receptor binding
protein heterodimerization activity
tau protein binding
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
protein tyrosine phosphatase activity

Annotation information from UniProt.

Sequence

MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 37 in total

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Pathway Name	Organism
APC truncation mutants have impaired AXIN binding	Homo sapiens
AXIN missense mutants destabilize the destruction complex	Homo sapiens
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	Homo sapiens
Beta-catenin phosphorylation cascade	Homo sapiens
CTLA4 inhibitory signaling	Homo sapiens
CTNNB1 S33 mutants aren't phosphorylated	Homo sapiens
CTNNB1 S37 mutants aren't phosphorylated	Homo sapiens
CTNNB1 S45 mutants aren't phosphorylated	Homo sapiens
CTNNB1 T41 mutants aren't phosphorylated	Homo sapiens
Cyclin A/B1/B2 associated events during G2/M transition	Homo sapiens