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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Versican core protein
Summary
- UniProt ID
- P81282
- Gene Symbol
-
- VCAN
- CSPG2
- Organism
- Bos taurus (domestic cattle)
External Links
Annotation
- Keyword
-
- Alternative splicing
- Calcium
- Cell projection
- Direct protein sequencing
- Disulfide bond
- EGF-like domain
- Extracellular matrix
- Hyaluronic acid
- Immunoglobulin domain
- Lectin
- Phosphoprotein
- Proteoglycan
- Reference proteome
- Repeat
- Signal
- Sushi
- Gene Ontology (GO)
| GO Term |
|---|
| positive regulation of neuroblast proliferation |
| skeletal system development |
| cell adhesion |
| central nervous system development |
| glial cell differentiation |
| GO Term |
|---|
| extracellular region |
| extracellular space |
| synapse |
| photoreceptor outer segment |
| interphotoreceptor matrix |
| perineuronal net |
| GO Term |
|---|
| calcium ion binding |
| carbohydrate binding |
| hyaluronic acid binding |
Sequence
MLINIKSILWMCSTLIAAHALQKVNMEKSPPVKGSLSGKVNLPCHFSTMPTLPPSYNTTSEFLRIKWSKIELDKTGKDLKETTVLVAQNGNIKIGQDYKGRVSVPTHPEDVGDASLTMVKLLASDAGRYRCDVMYGIEDTQDTVSLTVEGVVFHYRAATSRYTLNFEMAQKACVDIGAVIATPEQLHAAYEDGFEQCDAGWLSDQTVRYPIRVPREGCYGDMMGKEGVRTYGFRAPHETYDVYCYVDHLDGDVFHITAPNKFTFEEAGEECKTQDARLATVGELQAAWRNGFDRCDYGWLLDASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPTPDSRFDAYCFKPKQNISEATTIELNMLAETVSPTLLEELQVGLDRMTPIVPLITELPVITTKVPPIGNIVNFEQKSTVQPLTSTHRSATESLPPDGSMKKPWDMDYYSPSASGPLGEPDVSEIKEEVPQSTTVVSHHAPDSWDGVKEDLQIKDSVTQIEQIEVGPLVTSMEISKHIPSKEFTVTVTPFVSTTMTLESKTEKKAISTVSESVTTSHYGFTLREGDGEDRISTVRSGQSTSIFSQIPEVITVSKTSEDTTRGQLEDVESVSASTIVSPDSDGSPMDHRQEKQTHGRITEGFLGQYVSTTPFPSQHHTEVELFPYSGDKRLVEGTSTVISPTPRTGRERTETLRPAMRTVTYTNDEIQEKITKDSSIEKIEEEGFSGMKFPTASPEQIHHTKYSVGMTKSFESPALMTTTKPGVTPTEATDVEEDFTTPSGLETDGYQDTTEYEEGITTVHLIQSTLNVEVVTVSKWSLDEDNTTSKPLGSTEHVGSPKLPPALITTTGVSGKDKEMPSLTEDGRDEFTRIPGSTQRPLEEFTEEDTTDHEKFTVRFQPTTSIATTEKSTLRDSITEERVPPFTSTEVRVTHATIEGSALDEGEDVDVSKPLSTVPQFAHPSDVEGSTFVNYSSTQEPTTYVDTSHTIPLPVIPKTEWGVLVPSIPSEGEVLGEPSQDIRVINQTHFEASMYPETVRTTTEITQEATREDFLWKEQTPEKPVSPPSSTTDTAKETTPPLDEQESDGSAYTVFEDRSVMGSDRVSVLVTTPIGKFEQHTSFPPGAVTKAKTDEVVTLTPTTGSKVTFSPWPKQKYETEGTSPRGFVSPFSIGVTQLIEETTTEKREKTSLDYIDLGSGLFEKPKATELPEFSTVKATVPSDTAAFSSADRLHTPSASTEKPPLIDREPDEETTSDMVIIGESTSRVPPTTLEDIVAKKTETDIDREYFTTSSTSTTQPTRPPTVEGKEAFGPQAFSTPEPPAGTKFHPDINVYIIEVRENKTGRMSDFSVSGHPIDSESKEDEPCSEETDPEHDLIAEILPELLGMLHSEEDEEDEECANATDVTTTPSVQYINGKHVVTTVPKDPEAAEARRGQFESVAPSQNFSDSSESDSHQFIITHAGLPTAMQPNESKETTESLEITWRPEIYPETAEPFSSGEPDIFPTASIHEGEATEGPDSITEKNPELDHLVHEHAESVPLFPEESSGDAAIDQESQKIIFSGATEGTFGEEAEKSSTTHTPSMVASSVSAPVSEDASFILTGTPQSDEPLSTVESWVEITPRHTVEFSGSPSIPIPEGSGEAEEDKDKIFAMITDLSQRNTTDPRVTSDTSKIMITESLVDVPTTTIYSISEQVSAVVPTKFVRETDTYEWVFSPPLEETTRKEEEKGTTGTASTVEVHSPTQRLDQFVSPSELESSSETPPDDSAAATRKSFTSQMTPTQSERETTSSTVVFKETEVLDNLAAQTTDPSLSSQPGVLEVSPTVPGSPVSLFMEQGSGEAAVDPETTTVSSLSLNIEPEILAKEEAAGAWSPNVETVFPFEPTEQVLSTAVDREVAETISQTSKENLVSEISGEPTHRAEIKGFSTDFPLEEDFSGDFREYSTVSYPITKEEIVMMEGSGDAAFKDTQMLPSVTPTSDLSNHTADSEEPGSTLVSTSAFPWEEFTASAEGSGEPLLSVSSSVDQVFPSAAGKASGTDSPFIDQRLGEEGAINETDQRSTILPTAEAESTKASTEEGEVKENHTVSMDFPPTVEPDELWPRQEVNPVRQGNGSEIVSEEKTQEQESFEPLQSSVAPEQTTFDSQTFPEPGLQTTGYFTLTTKKTYSTDERMEEEVISLADVSTPTLDSKGLVLYTTLPEVTEKSHFFLATASVTESVPAESVIAGSTIKEEESIKPFPKVTSPIIKESDTDLIFSGLGSGEEVLPTLGSVNFTEIEQVLSTLYPLTSQVQSLEASILNDTSGDYEGMENVANEMRPLISKTDSIFEDGETASSTTLPEILSDARTEGPFTAPLTFSTGPGQPQNQTHRRAEEIQTSRPQPLTDQVSSENSVTAETKETATPATDFLARTYDLEMAKGFVTPTPKPSDLFYEHSGEGSGELDAVGAEVHASGMTQATRQGSTTFVSDRSLEKHPKVPSVEAVTVNGFPTVSMVLPLHPEQREGSPEATGTPASTASYEKATEGAADSFQDHFWGFKDSTLKPDKRKATESIIIDLDKEDKDLILTMTESTILEIIPELTSDKNTVIDIDHTKPIYEDILGMQTDLDPEVPSGPPDSSEESTQVQEKYEAAVNLSSTEENFEASGDILLANYTQATPESKAPEDRNPLDHTDFIFTTGIPILSSETELDVLLPTATSLPIPSKSATVNPESKTEAKTLEDIFESSTLSDGQAIADQSEVISTLGYLERTQNEDEAKKYVSPSFQPEFSSGAEEALTDPTPYVSIGTTYLTAQSLTEAPDVMEGARLPDSIDTSTVSAFSELLSQTPSFPPLSIHLGSGDSEHSEDLQPSALPSTDASTPPVSSGELANIEATFKPSSEEDFYITEPPSLPPDTEPSEDESKPKLLEPTEASATELIAQEEIEIFQNSDNTTSVQVSGEAVKVFPSIETPEAEAIVTAASETKLEGATLRPHSTSASVIHGVEAGVVPQPSPQTSERPTILSPLEISPETQAALIRGEDSTVAAPKQQVPTRMLDSNKQATLSTTELNTELATPSFPLLETSNETSFLIGINEESVEGTAVYLPGPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDRCELDFDECHSNPCRNGATCIDGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILSHEEQMFVNRVGHDYQWIGLNDKMFEHDFRWTDGSTLQYENWRPNQPDSFFSTGEDCVVIIWHENGQWNDVPCNYHLTYTCKKGTVACGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGFIQRHLPTIRCLGNGRWAMPKITCLNPSAYQRTYSKKYFKNSSSAKDNSINTSKHDHRWSRRWQESRR
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 57 | N-linked (GlcNAc...) asparagine |
|
||
| 331 | N-linked (GlcNAc...) asparagine |
|
||
| 352 | N-linked (GlcNAc...) asparagine |
|
||
| 660 | O-linked (Xyl...) (chondroitin sulfate) serine |
|
||
| 817 | N-linked (GlcNAc...) asparagine |
|
||
| 965 | N-linked (GlcNAc...) asparagine |
|
||
| 1017 | N-linked (GlcNAc...) asparagine |
|
||
| 1333 | N-linked (GlcNAc...) asparagine |
|
||
| 1393 | N-linked (GlcNAc...) asparagine |
|
||
| 1437 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| A tetrasaccharide linker sequence is required for GAG synthesis | Bos taurus |
| CS/DS degradation | Bos taurus |
| Chondroitin sulfate biosynthesis | Bos taurus |
| Dermatan sulfate biosynthesis | Bos taurus |
| ECM proteoglycans | Bos taurus |
| Post-translational protein phosphorylation | Bos taurus |
| Regulation of IGF Activity by IGFBP | Bos taurus |
