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Metabotropic glutamate receptor 1

Summary

UniProt ID

P97772

Gene Symbol

Gprc1a
Grm1
Mglur1

Gene ID

14816

Organism

Mus musculus (house mouse)

External Links

GlyGen: P97772
PubChem: P97772
Re-Glyco: P97772

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 10** entries
GO Term
nucleus
plasma membrane
dendrite
neuron projection
neuronal cell body
postsynaptic membrane
postsynaptic density
Schaffer collateral - CA1 synapse
glutamatergic synapse
G protein-coupled receptor homodimeric complex

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying **all 9** entries
GO Term
regulation of sensory perception of pain
locomotory behavior
sensory perception of pain
cellular response to electrical stimulus
L-glutamate import across plasma membrane
synaptic signaling via neuropeptide
positive regulation of MAPK cascade
phospholipase C-activating G protein-coupled receptor signaling pathway
phospholipase C-activating G protein-coupled glutamate receptor signaling pathway

Displaying **all 4** entries
GO Term
PLC activating G protein-coupled glutamate receptor activity
G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
glutamate receptor activity
G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential

Annotation information from UniProt.

Sequence

MVRLLLIFFPMIFLEMSILPRMPDRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGYVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGMVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEFVQDEFTCRACDLGWWPNAELTGCEPITIRYLEWSDIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPVGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKPGAGNANSNGKSVSWSEPGGRQAPKGQHVWQRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDASTKTLYNVEEEDNTPSTHFSPPSSPSMVVHRRGPPVATTPPLPPHLSAEETPLFLADSVIPKGLPPPLPQQQQQPPPQPPPQQPKSLMDQLQGVVTNFGSGIPDFHAVLAGPGTPGNGLRSLYPPPPPPQHLQMLPLQLSTFREEPISPPGEDDDDDSSERFKLLQEFVYEREGNTEEDDLEEEEDLPAASKLTPEDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVTYASVILRDYKQSSSTL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	GlyTouCan ID	Source
98	N-linked (GlcNAc...) asparagine	G01485JJ	UniProt GlyGen
223	N-linked (GlcNAc...) asparagine		UniProt GlyGen
397	N-linked (GlcNAc...) asparagine	G93910IH	UniProt GlyGen
515	N-linked (GlcNAc...) asparagine		UniProt GlyGen
747	N-linked (GlcNAc...) asparagine		UniProt GlyGen
1063			GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Class C/3 (Metabotropic glutamate/pheromone receptors)	Mus musculus
G alpha (q) signalling events	Mus musculus
Neurexins and neuroligins	Mus musculus

Disease

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0080062	autosomal recessive spinocerebellar ataxia 13	Alliance of Genome Resources
DOID:6039	uveal melanoma	Alliance of Genome Resources
DOID:8923	skin melanoma	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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External Links

Annotation

International Collaboration

Acknowledgements