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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
Summary
- UniProt ID
- Q00722
- Gene Symbol
-
- PLCB2
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q00722
- PubChem
- Q00722
- SwissLipids
- The Human Metabolome Database
- HMDBP00224
- The O-GlcNAc Database
- Q00722
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Calcium
- Coiled coil
- Hydrolase
- Lipid degradation
- Metal-binding
- Phosphoprotein
- Reference proteome
- Transducer
- Gene Ontology (GO)
| GO Term |
|---|
| cytoplasm |
| G-protein beta/gamma-subunit complex |
| cytosol |
| neuronal dense core vesicle |
Sequence
MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKESVRACLRTCFPSEAKDKPERACECPPELCEQDPLIAKADAQESRL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 849 |
|
|||
| 853 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Acetylcholine regulates insulin secretion | Homo sapiens |
| Ca2+ pathway | Homo sapiens |
| Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | Homo sapiens |
| G alpha (q) signalling events | Homo sapiens |
| G beta:gamma signalling through PLC beta | Homo sapiens |
| PLC beta mediated events | Homo sapiens |
| Presynaptic function of Kainate receptors | Homo sapiens |
| Sensory perception of sweet, bitter, and umami (glutamate) taste | Homo sapiens |
| Synthesis of IP3 and IP4 in the cytosol | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:11847 | coronary thrombosis | |
| DOID:1612 | breast cancer | |
| DOID:162 | cancer | |
| DOID:1909 | melanoma | |
| DOID:299 | adenocarcinoma | |
| DOID:3008 | invasive ductal carcinoma | |
| DOID:3459 | breast carcinoma | |
| DOID:3571 | liver cancer | |
| DOID:4766 | embryoma | |
| DOID:4903 | granular cell carcinoma |
