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Dual specificity mitogen-activated protein kinase kinase 1

Summary

UniProt ID

Q02750

Gene Symbol

MAP2K1
MEK1
PRKMK1

Organism

Homo sapiens (human)

External Links

GlyGen: Q02750
PubChem: Q02750

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Cardiomyopathy
Cytoskeleton
Direct protein sequencing
Disease variant
Ectodermal dysplasia
Intellectual disability
Membrane
Nucleus
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Tyrosine-protein kinase

Gene Ontology (GO)

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GO Term
keratinocyte differentiation
myelination
cell motility
epithelial cell proliferation involved in lung morphogenesis
thyroid gland development
regulation of stress-activated MAPK cascade
ERBB2-ERBB3 signaling pathway
Bergmann glial cell differentiation
face development
labyrinthine layer development

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GO Term
early endosome
late endosome
endoplasmic reticulum
Golgi apparatus
cytosol
nucleus
mitochondrion
plasma membrane
centrosome
spindle pole body

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GO Term
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
protein kinase activator activity
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase activity
MAP-kinase scaffold activity
ATP binding
protein serine/threonine kinase activator activity
scaffold protein binding

Annotation information from UniProt.

Sequence

MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
21			G40206WX	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Frs2-mediated activation	Homo sapiens
MAP2K and MAPK activation	Homo sapiens
MAP3K8 (TPL2)-dependent MAPK1/3 activation	Homo sapiens
MAPK3 (ERK1) activation	Homo sapiens
Negative feedback regulation of MAPK pathway	Homo sapiens
Paradoxical activation of RAF signaling by kinase inactive BRAF	Homo sapiens
RAF activation	Homo sapiens
Signal transduction by L1	Homo sapiens
Signaling by BRAF and RAF1 fusions	Homo sapiens
Signaling by MAP2K mutants	Homo sapiens