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Histone-lysine N-methyltransferase MECOM

Summary

UniProt ID

Q03112

Gene Symbol

MECOM
EVI1
MDS1
PRDM3

Organism

Homo sapiens (human)

External Links

GlyGen: Q03112
PubChem: Q03112
The Human Metabolome Database: HMDBP14555
The O-GlcNAc Database: Q03112

Annotation

Keyword

3D-structure
Acetylation
Alternative promoter usage
Alternative splicing
Apoptosis
Chromosomal rearrangement
Cytoplasm
DNA-binding
Developmental protein
Differentiation
Disease variant
Isopeptide bond
Methyltransferase
Nucleus
Phosphoprotein
Proto-oncogene
Reference proteome
Repeat
Transcription regulation
Ubl conjugation
Zinc-finger

Gene Ontology (GO)

Displaying **all 10** entries
GO Term
hematopoietic stem cell proliferation
heterochromatin organization
negative regulation of JNK cascade
regulation of transcription by RNA polymerase II
methylation
negative regulation of DNA-templated transcription
positive regulation of DNA-templated transcription
apoptotic process
regulation of cell cycle
negative regulation of programmed cell death

Displaying **all 4** entries
GO Term
nuclear speck
cytosol
nucleoplasm
nucleus

Displaying **all 10** entries
GO Term
DNA binding
metal ion binding
histone H3K9me2 methyltransferase activity
histone H3K9 monomethyltransferase activity
histone H3 methyltransferase activity
protein homodimerization activity
histone H3K9 methyltransferase activity
DNA-binding transcription activator activity, RNA polymerase II-specific
DNA-binding transcription factor activity
RNA polymerase II cis-regulatory region sequence-specific DNA binding

Annotation information from UniProt.

Sequence

MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGAGLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEILDEFYNVKFCIDASQPDVGSWLKYIRFAGCYDQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQQKLESENDLQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQSPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIESDKEKFKENGKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTKLTEPRKNHVFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQMSAIENMAEKLESFSALKPEASELLQSVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERMNGSHFKDEKALVTSQNSDLLDDEEVEDEVLLDEEDEDNDITGKTGKEPVTSNLHEGNPEDDYEETSALEMSCKTSPVRYKEEEYKSGLSALDHIRHFTDSLKMRKMEDNQYSEAELSSFSTSHVPEELKQPLHRKSKSQAYAMMLSLSDKESLHSTSHSSSNVWHSMARAAAESSAIQSISHV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites