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Fibroblast growth factor receptor 1

Summary

UniProt ID

Q04589

Gene Symbol

Fgfr1
Flg

Gene ID

79114

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: Q04589
Re-Glyco: Q04589

Annotation

Keyword

ATP-binding
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Heparin-binding
Immunoglobulin domain
Nucleus
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Gene Ontology (GO)

Displaying **all 8** entries
GO Term
nucleus
plasma membrane
cytoplasmic vesicle
receptor complex
postsynapse
cytosol
perinuclear region of cytoplasm
glutamatergic synapse

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

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GO Term
female pregnancy
sensory perception of sound
cell population proliferation
positive regulation of cell population proliferation
mesenchymal cell proliferation
regulation of gene expression
negative regulation of gene expression
cell projection assembly
lung development
response to nutrient levels

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GO Term
fibroblast growth factor binding
placental growth factor receptor activity
SH2 domain binding
identical protein binding
protein homodimerization activity
protein-containing complex binding
cell adhesion molecule binding
receptor-receptor interaction
GPI-linked ephrin receptor activity
transmembrane-ephrin receptor activity

Annotation information from UniProt.

Sequence

MWGWRGLLFWAVLVTATLCTARPAPTLPEQAQPWGVPVEVESLLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVRDSIPADSGLYACVTNSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRRPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPSPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYDQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIIYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPNPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWNAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQDSPSFPDTRSSTCSSGEDSVFSHEPFPEEPCLPRHPTQLANGGLNRR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	Source
77	N-linked (GlcNAc...) asparagine	UniProt
117	N-linked (GlcNAc...) asparagine	UniProt
227	N-linked (GlcNAc...) asparagine	UniProt
240	N-linked (GlcNAc...) asparagine	UniProt
264	N-linked (GlcNAc...) asparagine	UniProt
296	N-linked (GlcNAc...) asparagine	UniProt
317	N-linked (GlcNAc...) asparagine	UniProt
330	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Downstream signaling of activated FGFR1	Rattus norvegicus
FGFR1b ligand binding and activation	Rattus norvegicus
FGFR1c and Klotho ligand binding and activation	Rattus norvegicus
FGFR1c ligand binding and activation	Rattus norvegicus
FRS-mediated FGFR1 signaling	Rattus norvegicus
Negative regulation of FGFR1 signaling	Rattus norvegicus
PI-3K cascade:FGFR1	Rattus norvegicus
PI3K Cascade	Rattus norvegicus
PI3K/AKT Signaling	Rattus norvegicus
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Rattus norvegicus

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:6432	pulmonary hypertension	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements