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Prostaglandin G/H synthase 2

Summary

UniProt ID

Q05769

Gene Symbol

Ptgs2
Cox-2
Cox2
Pghs-b
Tis10

Organism

Mus musculus (house mouse)

External Links

GlyConnect

GlyGen

Q05769

PubChem

Q05769

SwissLipids

SLP:000001129

Annotation

Keyword

3D-structure
Acetylation
Dioxygenase
Direct protein sequencing
Disulfide bond
Glycoprotein
Heme
Membrane
Microsome
Nucleus
Peroxidase
Prostaglandin biosynthesis
Reference proteome
S-nitrosylation
Signal

Gene Ontology (GO)

Displaying entries **21 - 30** of 63 in total

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GO Term
response to vitamin D
positive regulation of vasoconstriction
prostaglandin biosynthetic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
learning
response to nematode
response to fructose
response to manganese ion
positive regulation of vascular endothelial growth factor production
prostaglandin secretion

Displaying **all 7** entries
GO Term
caveola
endoplasmic reticulum membrane
nuclear inner membrane
nuclear outer membrane
cytoplasm
protein-containing complex
neuron projection

Displaying **all 7** entries
GO Term
heme binding
protein homodimerization activity
peroxidase activity
prostaglandin-endoperoxide synthase activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
enzyme binding
metal ion binding

Site Annotations

Displaying 1 entry
Position	Description
592	Not glycosylated

Annotation information from UniProt.

Sequence

MLFRAVLLCAALGLSQAANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKYQVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRVAGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKALYSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFKIINTASIQSLICNNVKGCPFTSFNVQDPQPTKTATINASASHSRLDDINPTVLIKRRSTEL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
53	N-linked (GlcNAc...) asparagine	10811226 12925531 20463020 20810665 21467029 21489986 8349699 8967954	G48712ZJ G70101JE G80920RR G26335RK G64527OM G05724UK G43947VZ	UniProt GlyGen GlyConnect
130	N-linked (GlcNAc...) asparagine	10811226 12925531 20463020 20810665 21467029 21489986 8349699 8967954	G62768NK G48712ZJ G70101JE G26335RK G64527OM G05724UK G43947VZ G21001NA G39188ZX	UniProt GlyGen GlyConnect
396	N-linked (GlcNAc...) asparagine	10811226 12925531 20463020 20810665 21467029 21489986 8349699 8967954	G05724UK G43947VZ G21001NA G39188ZX G06110VR G45841FE G64581RP	UniProt GlyGen GlyConnect
580	N-linked (GlcNAc...) asparagine	20463020 8349699	G62765YT G05724UK G43947VZ G64581RP	UniProt GlyGen GlyConnect
			G62768NK G64581RP	GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
Biosynthesis of DHA-derived SPMs	Mus musculus
Biosynthesis of DPAn-3 SPMs	Mus musculus
Biosynthesis of EPA-derived SPMs	Mus musculus
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	Mus musculus
Nicotinamide salvaging	Mus musculus
Synthesis of 15-eicosatetraenoic acid derivatives	Mus musculus
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements