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Glial cell line-derived neurotrophic factor

Summary

UniProt ID

Q07731

Gene Symbol

Gdnf

Gene ID

25453

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: Q07731
Re-Glyco: Q07731

Annotation

Keyword

3D-structure
Alternative splicing
Cleavage on pair of basic residues
Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying **all 4** entries
GO Term
receptor complex
Golgi apparatus
extracellular region
extracellular space

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 46 in total

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GO Term
regulation of morphogenesis of a branching structure
nervous system development
peripheral nervous system development
positive regulation of cell population proliferation
regulation of gene expression
peristalsis
positive regulation of cell differentiation
positive regulation of transcription by RNA polymerase II
postsynaptic membrane organization
mesenchymal to epithelial transition involved in metanephros morphogenesis

Displaying **all 5** entries
GO Term
receptor tyrosine kinase binding
protein homodimerization activity
receptor ligand activity
glial cell-derived neurotrophic factor receptor binding
growth factor activity

Annotation information from UniProt.

Sequence

MKLWDVVAVCLVLLHTASAFPLPAGKRLLEAPAEDHSLGHRRVPFALTSDSNMPEDYPDQFDDVMDFIQATIKRLKRSPDKQAAALPRRERNRQAAAASPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCEAAETMYDKILKNLSRSRRLTSDKVGQACCRPVAFDDDLSFLDDSLVYHILRKHSAKRCGCI

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
126	N-linked (GlcNAc...) asparagine			UniProt
162	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
RAF/MAP kinase cascade	Rattus norvegicus
RET signaling	Rattus norvegicus

Disease

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:12700	hyperprolactinemia	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:3328	temporal lobe epilepsy	Alliance of Genome Resources
DOID:3525	middle cerebral artery infarction	Alliance of Genome Resources