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MIRAGE
Hyaluronidase-1

Summary
UniProt ID
Q12794
Gene Symbol
  • HYAL1
  • LUCA1
Gene ID
3373
Organism
Homo sapiens (human)
GlyGen
Q12794
PubChem
Q12794
The Human Metabolome Database
HMDBP09372
Re-Glyco
Q12794
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • EGF-like domain
  • Glycoprotein
  • Glycosidase
  • Lysosome
  • Mucopolysaccharidosis
  • Reference proteome
  • Secreted
  • Signal
Gene Ontology (GO)
Displaying all 6 entries
GO Term
extracellular space
lysosome
cytoplasmic vesicle
lysosomal lumen
extracellular exosome
hyaluranon cable
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVANPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAPDFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSRALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPLDELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRCYPGWQAPWCERKSMW
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 3 entries
Position Description PubMed ID GlyTouCan ID Source
99 N-linked (GlcNAc...) asparagine
216 N-linked (GlcNAc...) asparagine
350 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 3 entries
Pathway Name Organism
CS/DS degradation Homo sapiens
Hyaluronan uptake and degradation Homo sapiens
MPS IX - Natowicz syndrome Homo sapiens
Disease
Displaying all 2 entries
DO ID Disease Name Source
DOID:0050809 mucopolysaccharidosis IX
DOID:12798 mucopolysaccharidosis
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025