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cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

Summary

UniProt ID

Q13370

Gene Symbol

PDE3B

Organism

Homo sapiens (human)

External Links

GlyGen: Q13370
PubChem: Q13370
The Human Metabolome Database: HMDBP00578
The O-GlcNAc Database: Q13370
O-GlcNAcAtlas: Q13370

Annotation

Keyword

3D-structure
Alternative splicing
Angiogenesis
Hydrolase
Magnesium
Metal-binding
Phosphoprotein
Reference proteome
Transmembrane helix
cAMP
cGMP

Gene Ontology (GO)

Displaying entries **1 - 10** of 11 in total

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GO Term
angiogenesis
cAMP-mediated signaling
negative regulation of cell adhesion mediated by integrin
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
negative regulation of cell adhesion
G protein-coupled receptor signaling pathway
cellular response to insulin stimulus
negative regulation of angiogenesis
regulation of angiogenesis
negative regulation of lipid catabolic process

Displaying **all 5** entries
GO Term
endoplasmic reticulum
Golgi apparatus
membrane
guanyl-nucleotide exchange factor complex
cytosol

Displaying **all 7** entries
GO Term
metal ion binding
protein kinase B binding
calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-GMP phosphodiesterase activity

Annotation information from UniProt.

Sequence

MRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVELRPPPASPQQPRRCSPFCRARLSLGALAAFVLALLLGAEPESWAAGAAWLRTLLSVCSHSLSPLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDGDAGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGSLPSALRPLLSGLVGGAGCLLALGLDHFFQIREAPLHPRLSSAAEEKVPVIRPRRRSSCVSLGETAASYYGSCKIFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGNGVDLSVLNEARNMVSDLLTDPSLPPQVISSLRSISSLMGAFSGSCRPKINPLTPFPGFYPCSEIEDPAEKGDRKLNKGLNRNSLPTPQLRRSSGTSGLLPVEQSSRWDRNNGKRPHQEFGISSQGCYLNGPFNSNLLTIPKQRSSSVSLTHHVGLRRAGVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDTADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSGKSGEEENIFSKESFKLMETQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEEKCKADGNKLQVENSSLPQADEIQVIEEADEEE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites