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Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
Summary
- UniProt ID
- Q14191
- Gene Symbol
-
- WRN
- RECQ3
- RECQL2
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q14191
- PubChem
- Q14191
- The Human Metabolome Database
- HMDBP08834
- The O-GlcNAc Database
- Q14191
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Chromosome
- DNA repair
- DNA-binding
- Direct protein sequencing
- Disease variant
- Exonuclease
- Helicase
- Isomerase
- Isopeptide bond
- Magnesium
- Metal-binding
- Multifunctional enzyme
- Nucleus
- Phosphoprotein
- Reference proteome
- Repeat
- Ubl conjugation
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| regulation of growth rate |
| cellular response to gamma radiation |
| cellular senescence |
| replicative senescence |
| t-circle formation |
| positive regulation of strand invasion |
| GO Term |
|---|
| nucleus |
| chromosome |
| nucleolus |
| cytoplasm |
| nuclear speck |
| chromosome, telomeric region |
| nucleoplasm |
| centrosome |
| replication fork |
| GO Term |
|---|
| four-way junction helicase activity |
| MutLalpha complex binding |
| 3'-flap-structured DNA binding |
| 8-hydroxy-2'-deoxyguanosine DNA binding |
Sequence
MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Processing of DNA double-strand break ends | Homo sapiens |
| Processive synthesis on the C-strand of the telomere | Homo sapiens |
| Regulation of TP53 Activity through Phosphorylation | Homo sapiens |
| Removal of the Flap Intermediate from the C-strand | Homo sapiens |
| Resolution of D-loop Structures through Holliday Junction Intermediates | Homo sapiens |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | Homo sapiens |
| SUMOylation of DNA damage response and repair proteins | Homo sapiens |
