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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Ficolin-2
Summary
- UniProt ID
- Q15485
- Gene Symbol
-
- FCN2
- FCNL
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q15485
- The Human Metabolome Database
- HMDBP07683
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Calcium
- Collagen
- Complement activation lectin pathway
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Hydroxylation
- Lectin
- Metal-binding
- Reference proteome
- Repeat
- Secreted
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| signaling receptor binding |
| metal ion binding |
| carbohydrate derivative binding |
| proteoglycan binding |
| calcium-dependent protein binding |
| mannan binding |
| antigen binding |
Sequence
MELDRAVGVLGAATLLLSFLGMAWALQAADTCPEVKMVGLEGSDKLTILRGCPGLPGAPGPKGEAGTNGKRGERGPPGPPGKAGPPGPNGAPGEPQPCLTGPRTCKDLLDRGHFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRVDGSVDFYRDWATYKQGFGSRLGEFWLGNDNIHALTAQGTSELRVDLVDFEDNYQFAKYRSFKVADEAEKYNLVLGAFVEGSAGDSLTFHNNQSFSTKDQDNDLNTGNCAVMFQGAWWYKNCHVSNLNGRYLRGTHGSFANGINWKSGKGYNYSYKVSEMKVRPA
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Ficolins bind to repetitive carbohydrate structures on the target cell surface | Homo sapiens |
| Initial triggering of complement | Homo sapiens |
| Lectin pathway of complement activation | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060592 | B-cell adult acute lymphocytic leukemia | |
| DOID:0060851 | pemphigus vulgaris | |
| DOID:0070113 | Niemann-Pick disease type C1 | |
| DOID:0080146 | childhood B-cell acute lymphoblastic leukemia | |
| DOID:0080162 | lupus nephritis | |
| DOID:0080177 | hepatic veno-occlusive disease | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:0080324 | tuberous sclerosis 1 | |
| DOID:0080348 | Alzheimer's disease 1 | |
| DOID:0110035 | Alzheimer's disease 2 |
