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Tumor necrosis factor receptor type 1-associated DEATH domain protein

Summary

UniProt ID

Q15628

Gene Symbol

TRADD

Organism

Homo sapiens (human)

External Links

PubChem: Q15628

Annotation

Keyword

3D-structure
Alternative splicing
Apoptosis
Cytoskeleton
Glycoprotein
Nucleus
Reference proteome

Gene Ontology (GO)

Displaying entries **1 - 10** of 14 in total

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GO Term
apoptotic process
signal transduction
positive regulation of cell migration
positive regulation of apoptotic process
positive regulation of inflammatory response
TRAIL-activated apoptotic signaling pathway
positive regulation of NF-kappaB transcription factor activity
extrinsic apoptotic signaling pathway via death domain receptors
tumor necrosis factor-mediated signaling pathway
positive regulation of canonical NF-kappaB signal transduction

Displaying **all 9** entries
GO Term
nucleus
cytoplasm
cytoskeleton
plasma membrane
receptor complex
cytoplasmic side of plasma membrane
tumor necrosis factor receptor superfamily complex
death-inducing signaling complex
cytosol

Displaying **all 7** entries
GO Term
transmembrane receptor protein tyrosine kinase adaptor activity
death domain binding
tumor necrosis factor receptor binding
kinase binding
protein-macromolecule adaptor activity
identical protein binding
protein-containing complex binding

Annotation information from UniProt.

Sequence

MAAGQNGHEEWVGSAYLFVESSLDKVVLSDAYAHPQQKVAVYRALQAALAESGGSPDVLQMLKIHRSDPQLIVQLRFCGRQPCGRFLRAYREGALRAALQRSLAAALAQHSVPLQLELRAGAERLDALLADEERCLSCILAQQPDRLRDEELAELEDALRNLKCGSGARGGDGEVASAPLQPPVPSLSEVKPPPPPPPAQTFLFQGQPVVNRPLSLKDQQTFARSVGLKWRKVGRSLQRGCRALRDPALDSLAYEYEREGLYEQAFQLLRRFVQAEGRRATLQRLVEALEENELTSLAEDLLGLTDPNGGLA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
235	(Microbial infection) N-beta-linked (GlcNAc) arginine	23955153 30979585 32766249		UniProt
245	(Microbial infection) N-beta-linked (GlcNAc) arginine	32766249		UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 11 in total

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Pathway Name	Organism
CASP8 activity is inhibited	Homo sapiens
Defective RIPK1-mediated regulated necrosis	Homo sapiens
Dimerization of procaspase-8	Homo sapiens
Ligand-dependent caspase activation	Homo sapiens
RIPK1-mediated regulated necrosis	Homo sapiens
Regulation by c-FLIP	Homo sapiens
Regulation of TNFR1 signaling	Homo sapiens
Regulation of necroptotic cell death	Homo sapiens
TNF signaling	Homo sapiens
TNFR1-induced NF-kappa-B signaling pathway	Homo sapiens