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NPC intracellular cholesterol transporter 1 homolog 1

Summary

UniProt ID

Q19127

Gene Symbol

F02E8.6
ncr-1
npc-1

Gene ID

180719

Organism

Caenorhabditis elegans

External Links

GlycoProtDB: GPDB0000667
Re-Glyco: Q19127

Annotation

Keyword

Developmental protein
Disulfide bond
Glycoprotein
Lipid transport
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 3** entries
GO Term
lysosome
plasma membrane
late endosome

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying **all 7** entries
GO Term
sterol transport
cholesterol transport
cholesterol homeostasis
intestinal cholesterol absorption
positive regulation of growth rate
dauer larval development
regulation of egg-laying behavior

Displaying 1 entry
GO Term
cholesterol binding

Annotation information from UniProt.

Sequence

MKQLLIFCLLFGSIFHHGDAGCIMRGLCQKHTENAYGPCVTNDTNVEPTAFDKTHPAYEKMVEFCPHLLTGDNKLCCTPSQAEGLTKQIAQARHILGRCPSCFDNFAKLWCEFTCSPNQQDFVSISEMKPIEKKEGFTPEYQPAEAYVNTVEYRLSTDFAEGMFSSCKDVTFGGQPALRVMCTSTPCTLTNWLEFIGTQNLDLNIPIHTKFLLYDPIKTPPSDRSTYMNVNFTGCDKSARVGWPACSTSECNKEEYANLIDLDDGKTSGQTCNVHGIACLNIFVMLAFIGSLAVLLCVGFVFTSYDEDYTNLRQTQSGEESPKRNRIKRTGAWIHNFMENNARDIGMMAGRNPKSHFFIGCAVLIFCLPGMIYHKESTNVVDMWSSPRSRARQEEMVFNANFGRPQRYQQIMLLSHRDFQSSGKLYGPVFHKDIFEELFDILNAIKNISTQDSDGRTITLDDVCYRPMGPGYDCLIMSPTNYFQGNKEHLDMKSNKEETVSEDDDAFDYFSSEATTDEWMNHMAACIDQPMSQKTKSGLSCMGTYGGPSAPNMVFGKNSTNHQAANSIMMTILVTQRTEPEIQKAELWEKEFLKFCKEYREKSPKVIFSFMAERSITDEIENDAKDEIVTVVIALAFLIGYVTFSLGRYFVCENQLWSILVHSRICLGMLSVIINLLSSFCSWGIFSMFGIHPVKNALVVQFFVVTLLGVCRTFMVVKYYAQQRVSMPYMSPDQCPEIVGMVMAGTMPAMFSSSLGCAFSFFIGGFTDLPAIRTFCLYAGLAVLIDVVLHCTIFLALFVWDTQRELNGKPEFFFPYQIKDLLGAYLIGRQRATDTFMTQFFHFQVAPFLMHRMTRIITGIIFIASFITTVILSSKISVGFDQSMAFTEKSYISTHFRYLDKFFDVGPPVFFTVDGELDWHRPDVQNKFCTFPGCSDTSFGNIMNYAVGHTEQTYLSGEMYNWIDNYLEWISRKSPCCKVYVHDPNTFCSTNRNKSALDDKACRTCMDFDYVANSYPKSSIMYHRPSIEVFYRHLRHFLEDTPNSECVFGGRASFKDAISFTSRGRIQASQFMTFHKKLSISNSSDFIKAMDTARMVSRRLERSIDDTAHVFAYSKIFPFYEQYSTIMPILTTQLFITVVGVFGIICVTLGIDVKGAACAVICQVSNYFHIVAFMYIFNIPVNALSATNLVMSSGILIEFSVNVLKGYACSLRQRAKDRAESTVGSIGPIILSGPVVTMAGSTMFLSGAHLQIITVYFFKLFLITIVSSAVHALIILPILLAFGGSRGHGSSETSTNDNDEQHDACVLSPTAESHISNVEEGILNRPSLLDASHILDPLLKAEGGIDKAIDIITIDRSYPSTPSSLPCTSRMPRAHIEPDLRSL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	PubMed ID	Source
42	N-linked (GlcNAc...) asparagine		UniProt
231	N-linked (GlcNAc...) asparagine	17761667	GlycoProtDB UniProt
447	N-linked (GlcNAc...) asparagine		UniProt
558	N-linked (GlcNAc...) asparagine		UniProt
993	N-linked (GlcNAc...) asparagine		UniProt
1082	N-linked (GlcNAc...) asparagine		UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Intestinal lipid absorption	Caenorhabditis elegans

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14504	Niemann-Pick disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements