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Cystic fibrosis transmembrane conductance regulator

Summary

UniProt ID

Q1LX78

Gene Symbol

cftr

Gene ID

559080

Organism

Danio rerio (zebrafish)

External Links

PubChem: Q1LX78
Re-Glyco: Q1LX78

Annotation

Keyword

3D-structure
ATP-binding
Cell membrane
Chloride channel
Endoplasmic reticulum
Endosome
Glycoprotein
Isomerase
Phosphoprotein
Reference proteome
Repeat
Transmembrane helix

Gene Ontology (GO)

Displaying **all 8** entries
GO Term
plasma membrane
membrane
endoplasmic reticulum membrane
cytosol
apical plasma membrane
early endosome membrane
recycling endosome membrane
chloride channel complex

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 17 in total

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GO Term
regulation of neutrophil chemotaxis
respiratory burst involved in defense response
bicarbonate transport
T cell differentiation
defense response to bacterium
innate immune response
multicellular organismal-level water homeostasis
germ cell migration
embryonic hemopoiesis
transepithelial water transport

Displaying entries **1 - 10** of 13 in total

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GO Term
bicarbonate transmembrane transporter activity
isomerase activity
intracellularly ATP-gated chloride channel activity
DNA clamp loader activity
chloride channel activity
ATP binding
ATP hydrolysis activity
ATPase-coupled transmembrane transporter activity
ABC-type transporter activity
cohesin loader activity

Annotation information from UniProt.

Sequence

MQRSPVEDANCLSRYFFWWTNPIMRKGFKEKLRPSDVYQAPSQDAADILAERLEKEWDREVASGKKKPSLLRAMARCYIKPFLLFGFLLYIGEATKTVQPQLLGRIIASFDPAHEPERANGYFLAFGLGLLFTARFLLLQPAMFGLHHLGMQIRIALFSIIYKKTLKLSSRVLDKISTGQLVSLMSANLGKFDQSLGMAHFIWISPLQCILCTGLIWELIDVNSFCALAAISLLGVLQAFLSHKMGPYKAQKVLLTNKRLALTSEIMENLHSVKAYGWEEIMETLIKNIRQDEVKLTRKIGSLRYFYSSAYFFSAIFVIVAAVVPHALSRGINLRRIFTTLSYCMVLRMTVTRQLPGSIQMWYDTMRLIWKIEEFLSKEEYKLMEYDLSITELELQDVTASWDEGPGELLERIKQENKANGHHNGDAGLFFTNLYVAPVLKDISLKLKKGEMLAVTGSMGSGKSSLLMTILGELVPSSGKIRHSGRISYSSQTAWIMPGTIRDNILFGLTYDEYRYKSVVKACQLEEDLAALPEKDKTPMAEGGLNLSGGQKARVALARAVYRDADLYLLDAPFTHLDIATEKEIFDKCLCKLMASKTRILVTNKIEHLKRADKILLLHNGESFFYGTFPELQSERPDFSSLLLGLEAYDNISAERRCSILTETLHRVSVDESAGMQPERSAFRQVPPTKPMYIDERKASVIVNPLGVARKASFIQVPEEEVRRTLPDRKFSLVPENELVDESFMGSDVYHNHGVHMAGQRRQSVLAFMTNAQGQGRREHLQSSFRRRLSVVPQSELASELDIYTRRLSDSTYDMTGILEEENIEACLTDEIDEIEETFETTKWNTYVRYVSNNKSLLYVLIFILFIAAIEIAGSVAGIFLITDELWREEHQRSEPNMTKHSNASSSGQTYAITVTPTSSYYILYIYVATSESLLAMGFFRGLPFVHTTITISKKLHQKMLHAVLSAPMSVLNTMKTGRIMNRFTKDMATIDDMLPLLMFDFVQLTVVVVGCILVVSIVRPYIFLAATPLAIIFIVMRKYFLRTGQQLKQLETEARSPIFSHLIMSLKGLWTIRAFERQAYFEALFHKTLNTHTATWFLYLSTLRWFLFRADILFVFFFTLAAWIAVGTNQDKPGEIGIIICLAMLILGTFQWCVATSIAVDGMMRSVDRVFKFIDLPSETPKPDKGKDSDLIIENVDAQADSSWPHRGQIEVRNLTVKYTEAGHAVLKNLSFSAEGRQRVGILGRTGSGKSSLFNALLKLVYTDGEISIDGVNWNKMPLQKWRKAFGVVPQKVFIFTGPLRMNLDPYGCHSDEELWRVAEEVGLKTVIEQFPDKLDFQLEYGGYVLSNGHKQLICLARSILSGARILLLDEPSAHLDPVTIKVLKKTLRQSFSTCTILLSEHKVEPLLECQSFLMMDKGQVKTYDSIQKLLNETSHLKQAISPAERLKLFPRRNSSMRTPQSKLSSVTQTLQEEAEDNIQDTRL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
897	N-linked (GlcNAc...) asparagine			UniProt
903	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
ABC-family proteins mediated transport	Danio rerio
Aggrephagy	Danio rerio
RHO GTPases regulate CFTR trafficking	Danio rerio
RHOQ GTPase cycle	Danio rerio

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1485	cystic fibrosis	Alliance of Genome Resources
DOID:9351	diabetes mellitus	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements