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Neutrophil elastase

Summary

UniProt ID

Q3UP87

Gene Symbol

Ela2
Elane

Gene ID

50701

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0004873
PubChem: Q3UP87
The Human Metabolome Database: HMDBP13386
Re-Glyco: Q3UP87

Annotation

Keyword

Disulfide bond
Glycoprotein
Reference proteome
Serine protease
Signal

Gene Ontology (GO)

Displaying **all 6** entries
GO Term
extracellular space
cytoplasm
secretory granule
collagen-containing extracellular matrix
cell surface
transcription repressor complex

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 19 in total

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GO Term
proteolysis
phagocytosis
negative regulation of chemokine production
positive regulation of immune response
leukocyte migration
acute inflammatory response to antigenic stimulus
biosynthetic process of antibacterial peptides active against Gram-negative bacteria
neutrophil-mediated killing of fungus
negative regulation of transcription by RNA polymerase II
response to UV

Displaying **all 6** entries
GO Term
cytokine binding
serine-type endopeptidase activity
heparin binding
protease binding
transcription corepressor activity
peptidase activity

Annotation information from UniProt.

Sequence

MALGRLSSRTLAAMLLALFLGGPALASEIVGGRPARPHAWPFMASLQRRGGHFCGATLIARNFVMSAAHCVNGLNFRSVQVVLGAHDLRRQERTRQTFSVQRIFENGFDPSQLLNDIVIIQLNGSATINANVQVAQLPAQGQGVGDRTPCLAMGWGRLGTNRPSPSVLQELNVTVVTNMCRRRVNVCTLVPRRQAGICFGDSGGPLVCNNLVQGIDSFIRGGCGSGLYPDAFAPVAEFADWINSIIRSHNDHLLTHPKDREGRTN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
123	N-linked (GlcNAc...) asparagine			UniProt
172	N-linked (GlcNAc...) asparagine			GlycoProtDB UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Activation of Matrix Metalloproteinases	Mus musculus
Antimicrobial peptides	Mus musculus
Degradation of the extracellular matrix	Mus musculus
Neutrophil degranulation	Mus musculus
Pyroptosis	Mus musculus
Regulation of Complement cascade	Mus musculus