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Malonate--CoA ligase ACSF3, mitochondrial
Summary
- UniProt ID
- Q4G176
- Gene Symbol
-
- ACSF3
- PSEC0197
- Gene ID
- 197322
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- ATP-binding
- Fatty acid metabolism
- Ligase
- Mitochondrion
- Reference proteome
- Transit peptide
- Gene Ontology (GO)
| GO Term |
|---|
| mitochondrion |
| mitochondrial matrix |
| nucleoplasm |
| GO Term |
|---|
| long-chain fatty-acyl-CoA biosynthetic process |
| malonate catabolic process |
| fatty acid metabolic process |
| fatty acid biosynthetic process |
| GO Term |
|---|
| acid-thiol ligase activity |
| malonyl-CoA synthetase activity |
| very long-chain fatty acid-CoA ligase activity |
| ATP binding |
Sequence
MLPHVVLTFRRLGCALASCRLAPARHRGSGLLHTAPVARSDRSAPVFTRALAFGDRIALVDQHGRHTYRELYSRSLRLSQEICRLCGCVGGDLREERVSFLCANDASYVVAQWASWMSGGVAVPLYRKHPAAQLEYVICDSQSSVVLASQEYLELLSPVVRKLGVPLLPLTPAIYTGAVEEPAEVPVPEQGWRNKGAMIIYTSGTTGRPKGVLSTHQNIRAVVTGLVHKWAWTKDDVILHVLPLHHVHGVVNALLCPLWVGATCVMMPEFSPQQVWEKFLSSETPRINVFMAVPTIYTKLMEYYDRHFTQPHAQDFLRAVCEEKIRLMVSGSAALPLPVLEKWKNITGHTLLERYGMTEIGMALSGPLTTAVRLPGSVGTPLPGVQVRIVSENPQREACSYTIHAEGDERGTKVTPGFEEKEGELLVRGPSVFREYWNKPEETKSAFTLDGWFKTGDTVVFKDGQYWIRGRTSVDIIKTGGYKVSALEVEWHLLAHPSITDVAVIGVPDMTWGQRVTAVVTLREGHSLSHRELKEWARNVLAPYAVPSELVLVEEIPRNQMGKIDKKALIRHFHPS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 402 |
|
|||
| 415 |
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Synthesis of very long-chain fatty acyl-CoAs | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0111263 | combined malonic and methylmalonic acidemia |
