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RAC-beta serine/threonine-protein kinase
Summary
- UniProt ID
- Q60823
- Gene Symbol
-
- Akt2
- Gene ID
- 11652
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- ATP-binding
- Acetylation
- Apoptosis
- Cell membrane
- Cytoplasm
- Developmental protein
- Disulfide bond
- Endosome
- Glucose metabolism
- Glycogen biosynthesis
- Glycogen metabolism
- Glycoprotein
- Manganese
- Metal-binding
- Nucleus
- Phosphoprotein
- Reference proteome
- Serine/threonine-protein kinase
- Sugar transport
- Translation regulation
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| cytoplasm |
| plasma membrane |
| cell cortex |
| nucleoplasm |
| early endosome |
| cytosol |
| ruffle membrane |
| GO Term |
|---|
| histone H2AXS139 kinase activity |
| histone H2BS14 kinase activity |
| histone H2BS36 kinase activity |
| histone H3T45 kinase activity |
| histone H3S57 kinase activity |
Sequence
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRGPGEDAMDYKCGSPSDSSTSEMMEVAVNKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLGPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLDPLELDQRTHFPQFSYSASIRE
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| AKT phosphorylates targets in the cytosol | Mus musculus |
| AKT phosphorylates targets in the nucleus | Mus musculus |
| AKT-mediated inactivation of FOXO1A | Mus musculus |
| Activation of PKB | Mus musculus |
| CD28 dependent PI3K/Akt signaling | Mus musculus |
| CTLA4 inhibitory signaling | Mus musculus |
| Cyclin A:Cdk2-associated events at S phase entry | Mus musculus |
| Cyclin E associated events during G1/S transition | Mus musculus |
| Deactivation of the beta-catenin transactivating complex | Mus musculus |
| Downregulation of ERBB2:ERBB3 signaling | Mus musculus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:11612 | polycystic ovary syndrome | |
| DOID:9352 | type 2 diabetes mellitus |
