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BDNF/NT-3 growth factors receptor

Summary

UniProt ID

Q63604

Gene Symbol

Ntrk2
Trkb

Organism

Rattus norvegicus (Norway rat)

External Links

GlyGen: Q63604
PubChem: Q63604

Annotation

Keyword

ATP-binding
Alternative splicing
Cell membrane
Cell projection
Cytoplasm
Developmental protein
Differentiation
Disulfide bond
Endosome
Glycoprotein
Immunoglobulin domain
Leucine-rich repeat
Neurogenesis
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Synapse
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Gene Ontology (GO)

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GO Term
trans-synaptic signaling by neuropeptide, modulating synaptic transmission
positive regulation of glucocorticoid receptor signaling pathway
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
long-term synaptic potentiation
cellular response to brain-derived neurotrophic factor stimulus
negative regulation of anoikis
neuronal action potential propagation
brain-derived neurotrophic factor receptor signaling pathway
response to ethanol

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GO Term
perikaryon
cytosol
endosome
early endosome
cell surface
postsynaptic density
dendritic spine
perinuclear region of cytoplasm
Golgi membrane
plasma membrane

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GO Term
receptor tyrosine kinase binding
neurotrophin binding
protease binding
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
brain-derived neurotrophic factor receptor activity
protein homodimerization activity
brain-derived neurotrophic factor binding
transmembrane receptor protein serine/threonine kinase activity
neurotrophin receptor activity

Annotation information from UniProt.

Sequence

MSPWPRWHGPAMARLWGLCLLVLGFWRASLACPMSCKCSTTRIWCTEPSPGIVAFPRLEPNSIDPENITEILIANQKRLEIINEDDVEAYVGLKNLTIVDSGLKFVAYKAFLKNGNLRHINFTRNKLTSLSRRHFRHLDLSDLILTGNPFTCSCDIMWLKTLQETKSSPDTQDLYCLNESSKNTPLANLQIPNCGLPSARLAAPNLTVEEGKSVTISCSVGGDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVRGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLMAKNEYGKDERQISAHFMGRPGVDYETNPNYPEVLYEDWTTPTDIGDTTNKSNEIPSTDVADQTNREHLSVYAVVVIASVVGFCLLVMLLLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKNIHTLLQNLAKASPVYLDILG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	PubMed ID	GlyTouCan ID	Source
350	N-linked (GlcNAc...) asparagine			UniProt GlyGen
411	N-linked (GlcNAc...) asparagine			UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Activated NTRK2 signals through FRS2 and FRS3	Rattus norvegicus
Activated NTRK2 signals through PLCG1	Rattus norvegicus
NTRK2 activates RAC1	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements