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BDNF/NT-3 growth factors receptor

Summary

UniProt ID

Q63604

Gene Symbol

Ntrk2
Trkb

Organism

Rattus norvegicus (Norway rat)

External Links

GlyGen: Q63604
PubChem: Q63604

Annotation

Keyword

ATP-binding
Alternative splicing
Cell membrane
Cell projection
Cytoplasm
Developmental protein
Differentiation
Disulfide bond
Endosome
Glycoprotein
Immunoglobulin domain
Leucine-rich repeat
Neurogenesis
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Synapse
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Gene Ontology (GO)

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GO Term
learning
regulation of neurotransmitter secretion
retina development in camera-type eye
positive regulation of neuron projection development
glutamate secretion
regulation of metabolic process
central nervous system neuron development
cerebral cortex development
myelination in peripheral nervous system
mechanoreceptor differentiation

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GO Term
perikaryon
cytosol
endosome
early endosome

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GO Term
brain-derived neurotrophic factor receptor activity
protein homodimerization activity
brain-derived neurotrophic factor binding
transmembrane receptor protein serine/threonine kinase activity
neurotrophin receptor activity
ATP binding
receptor tyrosine kinase binding
neurotrophin binding
protease binding
protein tyrosine kinase activity

Annotation information from UniProt.

Sequence

MSPWPRWHGPAMARLWGLCLLVLGFWRASLACPMSCKCSTTRIWCTEPSPGIVAFPRLEPNSIDPENITEILIANQKRLEIINEDDVEAYVGLKNLTIVDSGLKFVAYKAFLKNGNLRHINFTRNKLTSLSRRHFRHLDLSDLILTGNPFTCSCDIMWLKTLQETKSSPDTQDLYCLNESSKNTPLANLQIPNCGLPSARLAAPNLTVEEGKSVTISCSVGGDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVRGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLMAKNEYGKDERQISAHFMGRPGVDYETNPNYPEVLYEDWTTPTDIGDTTNKSNEIPSTDVADQTNREHLSVYAVVVIASVVGFCLLVMLLLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKNIHTLLQNLAKASPVYLDILG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	PubMed ID	GlyTouCan ID	Source
67	N-linked (GlcNAc...) asparagine			UniProt GlyGen
95	N-linked (GlcNAc...) asparagine	24090084	G62765YT G31852PQ	UniProt GlyGen
121	N-linked (GlcNAc...) asparagine			UniProt GlyGen
178	N-linked (GlcNAc...) asparagine			UniProt GlyGen
205	N-linked (GlcNAc...) asparagine			UniProt GlyGen
241	N-linked (GlcNAc...) asparagine	24090084	G41247ZX G80966KZ G02815KT G55220VL G84552CD G92050GC	UniProt GlyGen
254	N-linked (GlcNAc...) asparagine			UniProt GlyGen
280	N-linked (GlcNAc...) asparagine			UniProt GlyGen
325	N-linked (GlcNAc...) asparagine			UniProt GlyGen
338	N-linked (GlcNAc...) asparagine			UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Activated NTRK2 signals through FRS2 and FRS3	Rattus norvegicus
Activated NTRK2 signals through PLCG1	Rattus norvegicus
NTRK2 activates RAC1	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

External Links

Annotation

International Collaboration

Acknowledgements