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MIRAGE
Monocyte differentiation antigen CD14
Summary
- UniProt ID
- Q63691
- Gene Symbol
-
- Cd14
- Gene ID
- 60350
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Cell membrane
- Disulfide bond
- GPI-anchor
- Golgi apparatus
- Inflammatory response
- Innate immunity
- Leucine-rich repeat
- Reference proteome
- Repeat
- Secreted
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular space |
| Golgi apparatus |
| external side of plasma membrane |
| cell surface |
| membrane raft |
| lipopolysaccharide receptor complex |
| GO Term |
|---|
| lipoteichoic acid binding |
| lipopolysaccharide binding |
| lipopolysaccharide immune receptor activity |
Sequence
MKLMLGLLLLPLTLVHASPATPEPCELDQDEESVRCYCNFSDPQPNWSSAFLCAGAEDVEFYGGGRSLEYLLKRVDTEANLGQYTDIIRSLPLKRLTVRSARVPTQILFGTLRVLGYSGLRELTLENLEVTGTALSPLLDATGPDLNTLSLRNVSWATTDTWLAELQQWLKPGLKVLSIAQAHSLNFSCKQVGVFPALATLDLSDNPELGEKGLISALCPHKFPTLQVLALRNAGMETTSGVCSALAAARVPLQALDLSHNSLRDTAGTPSCDWPSQLNSLNLSFTGLEHVPKGLPAKLSVLDLSYNRLDRKPRPEELPEVGSLSLTGNPFLHSESQSEAYNSGVVIATALSPGSAGLSGTLALLLGHRLFV
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | Rattus norvegicus |
| IKK complex recruitment mediated by RIP1 | Rattus norvegicus |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | Rattus norvegicus |
| Ligand-dependent caspase activation | Rattus norvegicus |
| MyD88-independent TLR4 cascade | Rattus norvegicus |
| Neutrophil degranulation | Rattus norvegicus |
| Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | Rattus norvegicus |
| Regulation of TLR by endogenous ligand | Rattus norvegicus |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | Rattus norvegicus |
| TRIF-mediated programmed cell death | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:8677 | perinatal necrotizing enterocolitis |
