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Monocyte differentiation antigen CD14

Summary

UniProt ID

Q63691

Gene Symbol

Cd14

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: Q63691

Annotation

Keyword

Cell membrane
Disulfide bond
GPI-anchor
Golgi apparatus
Inflammatory response
Innate immunity
Leucine-rich repeat
Reference proteome
Repeat
Secreted
Signal

Gene Ontology (GO)

Displaying entries **1 - 10** of 24 in total

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GO Term
positive regulation of cytokine production
response to molecule of bacterial origin
cell surface pattern recognition receptor signaling pathway
response to lipopolysaccharide
toll-like receptor 4 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
inflammatory response
response to bacterium
innate immune response
positive regulation of type I interferon production

Displaying **all 6** entries
GO Term
extracellular space
Golgi apparatus
lipopolysaccharide receptor complex
membrane raft
external side of plasma membrane
cell surface

Displaying **all 3** entries
GO Term
lipopolysaccharide binding
lipopolysaccharide immune receptor activity
lipoteichoic acid binding

Annotation information from UniProt.

Sequence

MKLMLGLLLLPLTLVHASPATPEPCELDQDEESVRCYCNFSDPQPNWSSAFLCAGAEDVEFYGGGRSLEYLLKRVDTEANLGQYTDIIRSLPLKRLTVRSARVPTQILFGTLRVLGYSGLRELTLENLEVTGTALSPLLDATGPDLNTLSLRNVSWATTDTWLAELQQWLKPGLKVLSIAQAHSLNFSCKQVGVFPALATLDLSDNPELGEKGLISALCPHKFPTLQVLALRNAGMETTSGVCSALAAARVPLQALDLSHNSLRDTAGTPSCDWPSQLNSLNLSFTGLEHVPKGLPAKLSVLDLSYNRLDRKPRPEELPEVGSLSLTGNPFLHSESQSEAYNSGVVIATALSPGSAGLSGTLALLLGHRLFV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	Source
39	N-linked (GlcNAc...) asparagine	UniProt
46	N-linked (GlcNAc...) asparagine	UniProt
153	N-linked (GlcNAc...) asparagine	UniProt
186	N-linked (GlcNAc...) asparagine	UniProt
282	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 12 in total

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Pathway Name	Organism
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	Rattus norvegicus
IKK complex recruitment mediated by RIP1	Rattus norvegicus
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	Rattus norvegicus
Ligand-dependent caspase activation	Rattus norvegicus
MyD88-independent TLR4 cascade	Rattus norvegicus
Neutrophil degranulation	Rattus norvegicus
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	Rattus norvegicus
Regulation of TLR by endogenous ligand	Rattus norvegicus
TRAF6-mediated induction of TAK1 complex within TLR4 complex	Rattus norvegicus
TRIF-mediated programmed cell death	Rattus norvegicus