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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Proprotein convertase subtilisin/kexin type 9
Summary
- UniProt ID
- Q80W65
- Gene Symbol
-
- Pcsk9
- Narc1
- Organism
- Mus musculus (house mouse)
External Links
- GlycoProtDB
- GPDB0006067
- PubChem
- Q80W65
Annotation
- Keyword
-
- Apoptosis
- Autocatalytic cleavage
- Calcium
- Cholesterol metabolism
- Cytoplasm
- Disulfide bond
- Endoplasmic reticulum
- Endosome
- Glycoprotein
- Golgi apparatus
- Lysosome
- Phosphoprotein
- Reference proteome
- Secreted
- Serine protease
- Signal
- Sulfation
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| cholesterol homeostasis |
| negative regulation of receptor recycling |
| negative regulation of receptor internalization |
| positive regulation of receptor internalization |
| kidney development |
| liver development |
| GO Term |
|---|
| extracellular region |
| extracellular space |
| endoplasmic reticulum |
| early endosome |
| late endosome |
| endoplasmic reticulum lumen |
| cell surface |
| COPII-coated ER to Golgi transport vesicle |
| perinuclear region of cytoplasm |
| cytoplasm |
Sequence
MGTHCSAWLRWPLLPLLPPLLLLLLLLCPTGAGAQDEDGDYEELMLALPSQEDGLADEAAHVATATFRRCSKEAWRLPGTYIVVLMEETQRLQIEQTAHRLQTRAARRGYVIKVLHIFYDLFPGFLVKMSSDLLGLALKLPHVEYIEEDSFVFAQSIPWNLERIIPAWHQTEEDRSPDGSSQVEVYLLDTSIQGAHREIEGRVTITDFNSVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGTSLHSLRVLNCQGKGTVSGTLIGLEFIRKSQLIQPSGPLVVLLPLAGGYSRILNAACRHLARTGVVLVAAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGKDIIGASSDCSTCFMSQSGTSQAAAHVAGIVARMLSREPTLTLAELRQRLIHFSTKDVINMAWFPEDQQVLTPNLVATLPPSTHETGGQLLCRTVWSAHSGPTRTATATARCAPEEELLSCSSFSRSGRRRGDWIEAIGGQQVCKALNAFGGEGVYAVARCCLVPRANCSIHNTPAARAGLETHVHCHQKDHVLTGCSFHWEVEDLSVRRQPALRSRRQPGQCVGHQAASVYASCCHAPGLECKIKEHGISGPSEQVTVACEAGWTLTGCNVLPGASLTLGAYSVDNLCVARVHDTARADRTSGEATVAAAICCRSRPSAKASWVQ
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 536 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| LDL clearance | Mus musculus |
| Post-translational protein phosphorylation | Mus musculus |
| Regulation of IGF Activity by IGFBP | Mus musculus |
| VLDLR internalisation and degradation | Mus musculus |
