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E3 ubiquitin-protein ligase Topors

Summary

UniProt ID

Q80Z37

Gene Symbol

Topors

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q80Z37
PubChem: Q80Z37
The O-GlcNAc Database: Q80Z37
O-GlcNAcAtlas: Q80Z37

Annotation

Keyword

DNA damage
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Transferase
Ubl conjugation
Ubl conjugation pathway
Zinc-finger

Gene Ontology (GO)

Displaying entries **1 - 10** of 13 in total

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GO Term
proteasome-mediated ubiquitin-dependent protein catabolic process
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
maintenance of protein location in nucleus
DNA damage response
positive regulation of DNA-templated transcription
protein polyubiquitination
ubiquitin-dependent protein catabolic process
protein monoubiquitination
intrinsic apoptotic signaling pathway in response to DNA damage
protein sumoylation

Displaying **all 9** entries
GO Term
nucleus
PML body
nuclear speck
ubiquitin ligase complex
spindle pole
gamma-tubulin complex
centriole
ciliary basal body
photoreceptor connecting cilium

Displaying **all 7** entries
GO Term
SUMO transferase activity
DNA topoisomerase binding
antigen binding
ubiquitin-protein transferase activity
ubiquitin protein ligase activity
DNA binding
metal ion binding

Annotation information from UniProt.

Sequence

MGSQPPPPGSPLSREEGEAPPLVPAEEGRRRSRRVRLRGSCRHRPSLLSRRELASNGPAVPATASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFTNPEVRRFRYRTTMTRERSASLYSPSSTVSRRTTTPPDSGVLFEGLGISTRPRDVDIPQFMRQMALRGPTTTDERSLRKIQEQDIINFRRTLYRAGVRVRSIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPPSSEEGSRSDSSVITISPDEAETQELDMNASTVRQAPWDDETPGPSYSSSEQVHVGVSSLLNSSDSSDEELVSGGTTSQIQGVQTNDDVNNDSDSSSDNCVIVGFVKPLAERTPELVELSSDSEELGPYEKVETVKTQEQEQSYSSGDSDVSRASSPRSVLGKDEQMSKSHCDSDTRISSKKEEKRSTSLPAPRDSSSTRGDRVCSPYNHRHRKGGRSRSSDSRSQSRSGHDPRNHRKHGKKRLRNKRSRSRESSSRPRARKDKKRSRTRDSSWSRRSQTLSLSSGSTSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSKYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPEFRIQSFSERTNARKKNHSERKYYYYERRRSRSVSSNRSRTTSAGPDRVRNEKPGGKRKYKTRHLEGTSEEAQPAREFTSKGKDSHYQKSKLDGSYKNESDSFSDSRSSDRETKHKRRRRRTRSLSVEIVYEGKATDTSKHHKKKKKKHKKKHKKHHGDNTSRSPVVITIDSDSDGESEVKAGIECSNGSLPQPIQDGAFETKDVVTIEDELGVLDKDCDVTALADDLSTSQTVENCDSPAVPVEQTLDVREESTFASDLESQSSNVSIQAEPSRPVPSPRTSLSSVSPGRDCDVS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites