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N6-adenosine-methyltransferase catalytic subunit

Summary

UniProt ID

Q86U44

Gene Symbol

METTL3
MTA70

Organism

Homo sapiens (human)

External Links

PubChem: Q86U44
The Human Metabolome Database: HMDBP00429
The O-GlcNAc Database: Q86U44

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Biological rhythms
Cytoplasm
DNA damage
Direct protein sequencing
Innate immunity
Isopeptide bond
Methyltransferase
Nucleus
Oogenesis
Phosphoprotein
RNA-binding
Reference proteome
S-adenosyl-L-methionine
Spermatogenesis
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 24 in total

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GO Term
positive regulation of cap-independent translational initiation
gliogenesis
innate immune response
regulation of T cell differentiation
positive regulation of translation
oogenesis
regulation of meiotic cell cycle
mRNA modification
forebrain radial glial cell differentiation
regulation of hematopoietic stem cell differentiation

Displaying **all 8** entries
GO Term
nucleoplasm
Golgi apparatus
cytosol
nucleus
nuclear body
nuclear speck
oxidoreductase complex
RNA N6-methyladenosine methyltransferase complex

Displaying **all 5** entries
GO Term
mRNA (N6-adenosine)-methyltransferase activity
RNA methyltransferase activity
S-adenosyl-L-methionine binding
mRNA binding
protein heterodimerization activity

Annotation information from UniProt.

Sequence

MSDTWSSIQAHKKQLDSLRERLQRRRKQDSGHLDLRNPEAALSPTFRSDSPVPTAPTSGGPKPSTASAVPELATDPELEKKLLHHLSDLALTLPTDAVSICLAISTPDAPATQDGVESLLQKFAAQELIEVKRGLLQDDAHPTLVTYADHSKLSAMMGAVAEKKGPGEVAGTVTGQKRRAEQDSTTVAAFASSLVSGLNSSASEPAKEPAKKSRKHAASDVDLEIESLLNQQSTKEQQSKKVSQEILELLNTTTAKEQSIVEKFRSRGRAQVQEFCDYGTKEECMKASDADRPCRKLHFRRIINKHTDESLGDCSFLNTCFHMDTCKYVHYEIDACMDSEAPGSKDHTPSQELALTQSVGGDSSADRLFPPQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQRYPDGIISKPKNL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites