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Serine/threonine-protein kinase tousled-like 2

Summary

UniProt ID

Q86UE8

Gene Symbol

TLK2

Organism

Homo sapiens (human)

External Links

GlyGen: Q86UE8
PubChem: Q86UE8
The Human Metabolome Database: HMDBP01439
The O-GlcNAc Database: Q86UE8

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell cycle
Chromatin regulator
Coiled coil
Cytoskeleton
DNA damage
Disease variant
Intellectual disability
Nucleus
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase

Gene Ontology (GO)

Displaying entries **1 - 10** of 11 in total

1

2

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GO Term
DNA damage response
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to gamma radiation
chromatin organization
protein phosphorylation
chromosome segregation
nucleus localization
negative regulation of autophagy
intracellular signal transduction
regulation of chromatin organization

Displaying **all 4** entries
GO Term
nucleoplasm
perinuclear region of cytoplasm
nucleus
intermediate filament

Displaying **all 4** entries
GO Term
identical protein binding
ATP binding
protein serine kinase activity
protein serine/threonine kinase activity

Annotation information from UniProt.

Sequence

MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites