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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
TIR domain-containing adapter molecule 2
Summary
- UniProt ID
- Q86XR7
- Gene Symbol
-
- TICAM2
- TIRAP3
- TIRP
- TRAM
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Cell projection
- Cytoplasm
- Endoplasmic reticulum
- Endosome
- Golgi apparatus
- Inflammatory response
- Innate immunity
- Myristate
- Phosphoprotein
- Reference proteome
- Gene Ontology (GO)
| GO Term |
|---|
| Golgi apparatus |
| plasma membrane |
| secretory granule membrane |
| cell projection |
| early endosome membrane |
| late endosome membrane |
| phagocytic cup |
| endosome |
| endoplasmic reticulum |
| endosome membrane |
| GO Term |
|---|
| molecular adaptor activity |
| protein kinase binding |
Sequence
MGIGKSKINSCPLSLSWGKRHSVDTSPGYHESDSKKSEDLSLCNVAEHSNTTEGPTGKQEGAQSVEEMFEEEAEEEVFLKFVILHAEDDTDEALRVQNLLQDDFGIKPGIIFAEMPCGRQHLQNLDDAVNGSAWTILLLTENFLRDTWCNFQFYTSLMNSVNRQHKYNSVIPMRPLNNPLPRERTPFALQTINALEEESRGFPTQVERIFQESVYKTQQTIWKETRNMVQRQFIA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | Homo sapiens |
| IKK complex recruitment mediated by RIP1 | Homo sapiens |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | Homo sapiens |
| Ligand-dependent caspase activation | Homo sapiens |
| MyD88-independent TLR4 cascade | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
| Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | Homo sapiens |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | Homo sapiens |
| TRIF-mediated programmed cell death | Homo sapiens |
| Toll Like Receptor 4 (TLR4) Cascade | Homo sapiens |
