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Two pore channel protein 2

Summary

UniProt ID

Q8BWC0

Gene Symbol

Tpcn2
Tpc2

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q8BWC0
The O-GlcNAc Database: Q8BWC0

Annotation

Keyword

Alternative splicing
Calcium channel
Endosome
Glycoprotein
Lysosome
Reference proteome
Repeat
Transmembrane helix
Voltage-gated channel

Gene Ontology (GO)

Displaying entries **1 - 10** of 14 in total

1

2

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GO Term
intracellular calcium ion homeostasis
smooth muscle contraction
lysosome organization
regulation of autophagy
regulation of exocytosis
calcium-mediated signaling
sodium ion transmembrane transport
negative regulation of developmental pigmentation
receptor-mediated endocytosis of virus by host cell
release of sequestered calcium ion into cytosol

Displaying **all 7** entries
GO Term
lysosome
lysosomal membrane
melanosome membrane
monoatomic ion channel complex
late endosome membrane
cytosol
endolysosome membrane

Displaying **all 7** entries
GO Term
voltage-gated calcium channel activity
NAADP-sensitive calcium-release channel activity
phosphatidylinositol-3,5-bisphosphate binding
intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity
protein kinase binding
ligand-gated sodium channel activity
identical protein binding

Annotation information from UniProt.

Sequence

MAAEEQPLLGRDRGSGQVHSGAAADQELCIDQAVVFIEDAIKYRSIYHRMDAGSLWLYRWYYSNVCQRVLGFIIFLILILAFVEVPSSFTKTADVRYRSQPWQPPCGLTETIEAFCLLAFLVDLSVKGYLVGQAQLQQNLWLLAYFMVLVVSVVDWIVSLSLACEEPLRMRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTIIGMLLFTIGEKDEAQDQERLAYFRNLPEALTSLLVLLTTSNNPDVMIPAYTQNRAFALFFIVFTLIGSLFLMNLLTAIIYNQFRGYLMKSLQTSLFRRRLGARAAYEVLASRAGPAGTTPELVGVNPETFLPVLQKTQLNKTHKQAIMQKVQSYEGRPMLADEFQKLFDEVDKGLAKERPLKPQYQSPFLQTAQFIFSHHYFDYLGNLVALGNLLSICVFLVLDSDLLPGERDDFVLGILDYIFILYYLLELLFKVFALGLPGYLSYHSNVFDGLLTIILLVSEICTLAVYRLPHSGWKPEQYGPLSLWDMTRLMNTLIVFRFLRIIPNIKPMAEVANTILGLIPNLRAFGGILVVAYYVFAMIGINLFRGVIVPPGNSSLVPDNNSAVCGSFEQLGYWPNNFDDFAAALITLWNVMVVNNWQVILEAYKRYAGPWSMVYFVLWWLVSSVIWINLFLALLLENFLHRWDPQGHKQLLVGTKQMSVELMFRDILEEPKEEELMEKLHKHPHLHLCR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
594	N-linked (GlcNAc...) asparagine	19557428		UniProt GlyGen
601	N-linked (GlcNAc...) asparagine	19557428		UniProt GlyGen
			G49108TO	GlyGen The O-GlcNAc Database