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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Nicastrin
Summary
- UniProt ID
- Q8CGU6
- Gene Symbol
-
- Ncstn
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Alternative splicing
- Cytoplasmic vesicle
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Notch signaling pathway
- Reference proteome
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| amyloid-beta formation |
| amyloid precursor protein catabolic process |
| amyloid-beta metabolic process |
| regulation of long-term synaptic potentiation |
| short-term synaptic potentiation |
| GO Term |
|---|
| lysosome |
| lysosomal membrane |
| Golgi apparatus |
| plasma membrane |
| membrane |
| protein-containing complex |
| melanosome |
| cytoplasmic vesicle membrane |
| synaptic membrane |
| sarcolemma |
Sequence
MATARGGSGPDPGSRGLLLLSFSVVLAGLCGGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEDDLKWVLTDGPNPPYMVLLEGKLFTRDIMEKLKGETSRIAGLAVTLAKPNSTSSFSPSVQCPNDGFGIYSNSYGPEFAHCKKTLWNELGNGLAYDDFSFPIFLLEDENETKVIKQCYQDHNLGQNGSAPSFPLCAMQLFSHMHAVISTATCMRRSFIQSTFSINPEIVCDPLSDYNVWSMLKPINTSGGLEPDVRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALHKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMENGKFPVRLENIDSFVELGQVALRTSLELWMHTDPMSQKNESVKNQVEDLLVTLEQSGADTPQVVLSRLVQSQALPPSSLQRFLRARNISGVVLADHSGSFHNRYYQSIYDTAENINVTYPESQSPEEDLNFVTDTAKALADVATVLARALYKLAGGTNFNNSIQADPQTVTRLLYGFLVRANNSWFQSILRHDLRSYLDDGPLQHYIAVSSPTNTTYVVQYALANLTGKVTNLTQEQCQDPSKVPNESKDLYEYSWVQGPWNSNKTERLPRCVRSTVRLARALSPAFELSQWSSTEYSTWAESRWKDIQARIFLIASKELEFITLIVGFSILVFSLIVTYCINAKADVLFVAPREPGAVSY
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 529 | N-linked (GlcNAc...) asparagine |
|
||
| 561 | N-linked (GlcNAc...) asparagine |
|
||
| 572 | N-linked (GlcNAc...) asparagine |
|
||
| 579 | N-linked (GlcNAc...) asparagine |
|
||
| 593 | N-linked (GlcNAc...) asparagine |
|
||
| 611 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| EPH-ephrin mediated repulsion of cells | Rattus norvegicus |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | Rattus norvegicus |
| NRIF signals cell death from the nucleus | Rattus norvegicus |
| Neutrophil degranulation | Rattus norvegicus |
| Noncanonical activation of NOTCH3 | Rattus norvegicus |
| Nuclear signaling by ERBB4 | Rattus norvegicus |
| Regulated proteolysis of p75NTR | Rattus norvegicus |
