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Coagulation factor VII

Summary

UniProt ID

Q8K3U6

Gene Symbol

Gene ID

260320

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: Q8K3U6
Re-Glyco: Q8K3U6

Annotation

Keyword

Blood coagulation
Calcium
Cleavage on pair of basic residues
Disulfide bond
EGF-like domain
Gamma-carboxyglutamic acid
Glycoprotein
Hydroxylation
Reference proteome
Repeat
Secreted
Serine protease
Signal
Zymogen

Gene Ontology (GO)

Displaying **all 3** entries
GO Term
vesicle
serine-type peptidase complex
extracellular space

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 26 in total

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GO Term
response to hypoxia
positive regulation of leukocyte chemotaxis
response to estrogen
positive regulation of positive chemotaxis
response to thyroid hormone
response to organic cyclic compound
response to carbon dioxide
response to growth hormone
response to cholesterol
blood coagulation

Displaying **all 4** entries
GO Term
serine-type endopeptidase activity
signaling receptor binding
calcium ion binding
endopeptidase activity

Annotation information from UniProt.

Sequence

MVPQTHGLLLLYFLLQLQGPLGAVVFITQEEAHGVLHRQRRANSLLEELWSSSLERECNEERCSFEEAREIFKSPERTKQFWTIYSDGDQCASNPCQNGGTCQDHLKSYVCFCPLDFEGRNCEKNKNEQLICANENGDCDQYCRDHVGTKRTCSCHEDYVLQPDEVSCKPKVEYPCGRIPVVEKRNFSRPQGRIVGGYVCPKGECPWQAVLKFNEALLCGAVLLDTRWIVTAAHCFDKFGKLVNITVVLGEHDFSEKEGTEQVRLVEQVIMPNKYTRGRTDHDIALVRLHRPVTFTDYVVPLCLPERAFSENTLASIRFSRVSGWGQLLDRGATALELMVIEVPRLMTQDCLEHAKHSANTPRITENMFCAGYMDGTKDACKGDSGGPHATHYHGTWYLTGVVSWGEGCAAIGHIGVYTRVSQYIDWLVKYMDSKLRVGISRVSLL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
93	O-linked (Xyl...) serine; alternate	UniProt
101	O-linked (Fuc) threonine	UniProt
186	N-linked (GlcNAc...) asparagine	UniProt
244	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Extrinsic Pathway of Fibrin Clot Formation	Rattus norvegicus
Gamma-carboxylation of protein precursors	Rattus norvegicus
Removal of aminoterminal propeptides from gamma-carboxylated proteins	Rattus norvegicus
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	Rattus norvegicus

Disease

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:2841	asthma	Alliance of Genome Resources
DOID:9351	diabetes mellitus	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements