Proprotein convertase subtilisin/kexin type 9

Summary
UniProt ID
Q8NBP7
Gene Symbol
  • PCSK9
  • NARC1
Organism
Homo sapiens (human)
External Links
GlycoProtDB
GPDB0012409
GlyGen
Q8NBP7
PubChem
Q8NBP7
The Human Metabolome Database
HMDBP07935
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Apoptosis
  • Autocatalytic cleavage
  • Calcium
  • Cholesterol metabolism
  • Cytoplasm
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Endoplasmic reticulum
  • Endosome
  • Glycoprotein
  • Golgi apparatus
  • Lysosome
  • Phosphoprotein
  • Reference proteome
  • Secreted
  • Serine protease
  • Signal
  • Sulfation
  • Zymogen
Gene Ontology (GO)
Sequence
MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPDEELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAPPAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASCCHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRDVSTTGSTSEGAVTAVAICCRSRHLAQASQELQ
Glycosylation Sites
Displaying 1 entry
Position Description PubMed ID GlyTouCan ID Source
533 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 4 entries
Pathway Name Organism
LDL clearance Homo sapiens
Post-translational protein phosphorylation Homo sapiens
Regulation of IGF Activity by IGFBP Homo sapiens
VLDLR internalisation and degradation Homo sapiens

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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024