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Proprotein convertase subtilisin/kexin type 9

Summary

UniProt ID

Q8NBP7

Gene Symbol

PCSK9
NARC1

Organism

Homo sapiens (human)

External Links

GlycoProtDB: GPDB0012409
GlyGen: Q8NBP7
PubChem: Q8NBP7
The Human Metabolome Database: HMDBP07935

Annotation

Keyword

3D-structure
Alternative splicing
Apoptosis
Autocatalytic cleavage
Calcium
Cholesterol metabolism
Cytoplasm
Direct protein sequencing
Disease variant
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Lysosome
Phosphoprotein
Reference proteome
Secreted
Serine protease
Signal
Sulfation
Zymogen

Gene Ontology (GO)

Displaying entries **1 - 10** of 27 in total

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GO Term
apoptotic process
lysosomal transport
neuron differentiation
cellular response to insulin stimulus
regulation of signaling receptor activity
neurogenesis
lipoprotein metabolic process
regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
negative regulation of sodium ion transmembrane transporter activity

Displaying entries **11 - 18** of 18 in total

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GO Term
lysosomal membrane
Golgi apparatus
plasma membrane
PCSK9-LDLR complex
PCSK9-AnxA2 complex
extrinsic component of external side of plasma membrane
extracellular region
extracellular space

Displaying entries **1 - 10** of 11 in total

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GO Term
signaling receptor inhibitor activity
apolipoprotein binding
low-density lipoprotein particle receptor binding
sodium channel inhibitor activity
very-low-density lipoprotein particle binding
serine-type endopeptidase activity
low-density lipoprotein particle binding
apolipoprotein receptor binding
protein self-association
very-low-density lipoprotein particle receptor binding

Annotation information from UniProt.

Sequence

MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPDEELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAPPAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASCCHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRDVSTTGSTSEGAVTAVAICCRSRHLAQASQELQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
533	N-linked (GlcNAc...) asparagine	16912035	G83460ZZ	GlycoProtDB UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
LDL clearance	Homo sapiens
Post-translational protein phosphorylation	Homo sapiens
Regulation of IGF Activity by IGFBP	Homo sapiens
VLDLR internalisation and degradation	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements