GlyCosmos Portal

Submissions

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Summary

UniProt ID

Q8TEK3

Gene Symbol

DOT1L
KIAA1814
KMT4

Organism

Homo sapiens (human)

External Links

GlyGen: Q8TEK3
PubChem: Q8TEK3
The Human Metabolome Database: HMDBP00402
The O-GlcNAc Database: Q8TEK3
RaftProt: Q8TEK3
O-GlcNAcAtlas: Q8TEK3

Annotation

Keyword

3D-structure
Alternative splicing
Chromatin regulator
DNA-binding
Disease variant
Methyltransferase
Nucleus
Phosphoprotein
Reference proteome
Repeat
S-adenosyl-L-methionine

Gene Ontology (GO)

Displaying **all 10** entries
GO Term
telomere organization
heterochromatin formation
regulation of receptor signaling pathway via JAK-STAT
positive regulation of cell population proliferation
gene expression
DNA repair
methylation
positive regulation of transcription by RNA polymerase II
regulation of transcription regulatory region DNA binding
DNA damage checkpoint signaling

Displaying **all 5** entries
GO Term
protein-containing complex
intracellular membrane-bounded organelle
nucleoplasm
nucleus
cytoplasm

Displaying **all 8** entries
GO Term
RNA polymerase II-specific DNA-binding transcription factor binding
histone H3 methyltransferase activity
histone H3K79 methyltransferase activity
transcription coactivator activity
histone methyltransferase activity
histone H3K79 trimethyltransferase activity
nucleic acid binding
DNA binding

Annotation information from UniProt.

Sequence

MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGGGLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLKGEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites