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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
ER degradation-enhancing alpha-mannosidase-like protein 1
Summary
- UniProt ID
- Q92611
- Gene Symbol
-
- EDEM1
- EDEM
- KIAA0212
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Alternative splicing
- Endoplasmic reticulum
- Glycoprotein
- Reference proteome
- Signal-anchor
- Transmembrane helix
- Unfolded protein response
- Gene Ontology (GO)
| GO Term |
|---|
| endoplasmic reticulum |
| endoplasmic reticulum membrane |
| aggresome |
| endoplasmic reticulum quality control compartment |
| GO Term |
|---|
| mannosyl-oligosaccharide 1,2-alpha-mannosidase activity |
| calcium ion binding |
| misfolded protein binding |
Sequence
MQWRALVLGLVLLRLGLHGVLWLVFGLGPSMGFYQRFPLSFGFQRLRSPDGPASPTSGPVGRPGGVSGPSWLQPPGTGAAQSPRKAPRRPGPGMCGPANWGYVLGGRGRGPDEYEKRYSGAFPPQLRAQMRDLARGMFVFGYDNYMAHAFPQDELNPIHCRGRGPDRGDPSNLNINDVLGNYSLTLVDALDTLAIMGNSSEFQKAVKLVINTVSFDKDSTVQVFEATIRVLGSLLSAHRIITDSKQPFGDMTIKDYDNELLYMAHDLAVRLLPAFENTKTGIPYPRVNLKTGVPPDTNNETCTAGAGSLLVEFGILSRLLGDSTFEWVARRAVKALWNLRSNDTGLLGNVVNIQTGHWVGKQSGLGAGLDSFYEYLLKSYILFGEKEDLEMFNAAYQSIQNYLRRGREACNEGEGDPPLYVNVNMFSGQLMNTWIDSLQAFFPGLQVLIGDVEDAICLHAFYYAIWKRYGALPERYNWQLQAPDVLFYPLRPELVESTYLLYQATKNPFYLHVGMDILQSLEKYTKVKCGYATLHHVIDKSTEDRMESFFLSETCKYLYLLFDEDNPVHKSGTRYMFTTEGHIVSVDEHLRELPWKEFFSEEGGQDQGGKSVHRPKPHELKVINSSSNCNRVPDERRYSLPLKSIYMRQIDQMVGLI
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 56 |
|
|
||
| 181 | N-linked (GlcNAc...) asparagine |
|
||
| 198 | N-linked (GlcNAc...) asparagine |
|
||
| 299 | N-linked (GlcNAc...) asparagine |
|
||
| 342 | N-linked (GlcNAc...) asparagine | |||
| 624 | N-linked (GlcNAc...) asparagine | |||
| 628 |
|
|
||
| 630 |
|
|
G17208MA
G25079LO
G62765YT
G83460ZZ
G80920RR
G31852PQ
G41247ZX
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| ER Quality Control Compartment (ERQC) | Homo sapiens |
| XBP1(S) activates chaperone genes | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
