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Major prion protein

Summary

UniProt ID

Q95211

Gene Symbol

PRNP
PRP

Organism

Oryctolagus cuniculus (rabbit)

External Links

PubChem: Q95211

Annotation

Keyword

3D-structure
Cell membrane
Copper
Disulfide bond
GPI-anchor
Golgi apparatus
Metal-binding
Prion
Reference proteome
Repeat
Signal
Zinc

Gene Ontology (GO)

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GO Term
positive regulation of protein targeting to membrane
regulation of potassium ion transmembrane transport
negative regulation of amyloid-beta formation
negative regulation of dendritic spine maintenance
cellular response to amyloid-beta
regulation of calcium ion import across plasma membrane

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GO Term
endoplasmic reticulum

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GO Term
protease binding
glycosaminoglycan binding
microtubule binding
signaling receptor activity
molecular condensate scaffold activity
cupric ion binding
cuprous ion binding
protein-containing complex binding
aspartic-type endopeptidase inhibitor activity
type 5 metabotropic glutamate receptor binding

Annotation information from UniProt.

Sequence

MAHLGYWMLLLFVATWSDVGLCKKRPKPGGGWNTGGSRYPGQSSPGGNRYPPQGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGTHNQWGKPSKPKTSMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNSFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQQESQAAYQRAAGVLLFSSPPVILLISFLIFLIVG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites