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MIRAGE
Methionine--tRNA ligase, mitochondrial

Summary
UniProt ID
Q96GW9
Gene Symbol
  • MARS2
Gene ID
92935
Organism
Homo sapiens (human)
GlyGen
Q96GW9
PubChem
Q96GW9
The Human Metabolome Database
HMDBP09251
The O-GlcNAc Database
Q96GW9
O-GlcNAcAtlas
Q96GW9
Re-Glyco
Q96GW9
Annotation
Keyword
  • ATP-binding
  • Aminoacyl-tRNA synthetase
  • Deafness
  • Disease variant
  • Mitochondrion
  • Neurodegeneration
  • Primary mitochondrial disease
  • Protein biosynthesis
  • Reference proteome
  • Transit peptide
Gene Ontology (GO)
Displaying all 2 entries
GO Term
mitochondrion
mitochondrial matrix
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying all 2 entries
GO Term
ATP binding
methionine-tRNA ligase activity
Annotation information from UniProt.
Sequence
MLRTSVLRLLGRTGASRLSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPIFYVNAAPHIGHLYSALLADALCRHRRLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQFQQLFQEAGISCTDFIRTTEARHRVAVQHFWGVLKSRGLLYKGVYEGWYCASDECFLPEAKVTQQPGPSGDSFPVSLESGHPVSWTKEENYIFRLSQFRKPLQRWLRGNPQAITPEPFHHVVLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNAEFKSWWPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRICVHSHWTVCGQKMSKSLGNVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAKRINPSETYPAFCTTCFPSEPGLVGPSVRAQAEDYALVSAVATLPKQVADHYDNFRIYKALEAVSSCVRQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALECLRVFGTLLQPVTPSLADKLLSRLGVSASERSLGELYFLPRFYGHPCPFEGRRLGPETGLLFPRLDQSRTWLVKAHRT
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 2 entries
Position Description PubMed ID GlyTouCan ID Source
131
528
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying 1 entry
Pathway Name Organism
Mitochondrial tRNA aminoacylation Homo sapiens
Disease
Displaying all 2 entries
DO ID Disease Name Source
DOID:0050942 spastic ataxia 3
DOID:0111468 combined oxidative phosphorylation deficiency 25
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025