GlyCosmos Portal

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Protein smoothened

Summary

UniProt ID

Q99835

Gene Symbol

SMO
SMOH

Organism

Homo sapiens (human)

External Links

GlyConnect

2079

GlyGen

Q99835

PubChem

Q99835

The O-GlcNAc Database

Q99835

O-GlcNAcAtlas

Q99835

Annotation

Keyword

3D-structure
Cell membrane
Cell projection
Developmental protein
Disease variant
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **31 - 40** of 67 in total

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GO Term
positive regulation of multicellular organism growth
odontogenesis of dentin-containing tooth
negative regulation of apoptotic process
negative regulation of DNA binding
positive regulation of organ growth
skeletal muscle fiber development
smooth muscle tissue development
forebrain morphogenesis
homeostasis of number of cells within a tissue
myoblast migration

Displaying entries **11 - 14** of 14 in total

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GO Term
endoplasmic reticulum-Golgi intermediate compartment
centriole
ciliary tip
9+0 non-motile cilium

Displaying **all 6** entries
GO Term
G protein-coupled receptor activity
cAMP-dependent protein kinase inhibitor activity
patched binding
oxysterol binding
protein kinase A catalytic subunit binding
protein sequestering activity

Annotation information from UniProt.

Sequence

MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTELMDADSDF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 9** entries
Position	Description	GlyTouCan ID	Source
35	N-linked (GlcNAc...) asparagine	G08293MJ G84452RH	UniProt GlyGen GlyConnect
47		G49108TO	GlyGen
55		G43417UB	GlyGen
188	N-linked (GlcNAc...) asparagine	G83460ZZ	UniProt GlyGen
309	N-linked (GlcNAc...) asparagine		UniProt GlyGen
446		G95995BI	GlyGen
493		G83460ZZ	GlyGen
500		G29068FM	GlyGen
		G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Activation of SMO	Homo sapiens
BBSome-mediated cargo-targeting to cilium	Homo sapiens
Class B/2 (Secretin family receptors)	Homo sapiens
Hedgehog 'off' state	Homo sapiens
Hedgehog 'on' state	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

International Collaboration

Acknowledgements